ArticlebioRxiv : the preprint server for biology2025
Epidermal γδ T cells, CD8 T cells and macrophages are increased in number in alopecia areata and express BST2 as part of an interferon-driven antiviral gene signature.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alopecia areata is an autoimmune disorder affecting approximately 2% of the global population, characterized by immune-mediated disruption of hair follicle immune privilege and unpredictable hair loss. While CD4 and CD8 T cells are established drivers of pathogenesis, the roles of other immune cell populations remain incompletely defined. Here, we reaffirm the pathogenic role of CD8 T cells and identify a contribution of epidermal γδ T cells and macrophages to alopecia areata. Using publicly available single-cell RNA sequencing (scRNAseq) data from the skin of C3H/HeJ mice with alopecia areata, we demonstrate that epidermal γδ T cells upregulate genes associated with immune homeostasis, proliferation, and inflammation, including
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