ArticlebioRxiv : the preprint server for biology2025
HIF-1α+ CD4 T cells coordinate a tissue resident immune cell network in the lung.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Corrections and comments
- Updated byHIF-1α2026
Authors and funding
13 authors.
Funding
Abstract
A deeper understanding of how tissue localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no murine models that specifically target tissue T cells while leaving their lymphoid counterparts untouched. Here we leverage the observation that during influenza infection, HIF-1α regulatory activity is higher in the lung compared to lymph node CD4 T cells. Inducible deletion of
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Registered trials
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