Evidence map›Paper›PMID 40667355›Full record

ArticlebioRxiv : the preprint server for biology2025

Pathogenic strains of a gut commensal drive systemic platelet activation and thromboinflammation in lupus nephritis.

Abhimanyu Amarnani, Cristobal F Rivera, Macintosh Cornwell, Tyler Weinstein, Susan R S Gottesman, Cynthia Loomis, Zakia Azad, Andy Lee, Joshua Prasad, Betsy Barnes and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Abhimanyu AmarnaniDivision of Rheumatology, NYU Grossman School of Medicine, New York, NY.
Cristobal F RiveraDepartment of Cell Biology, NYU Grossman School of Medicine, New York, NY.
Macintosh CornwellDivision of Precision Medicine, NYU Grossman School of Medicine, New York, NY.
Tyler WeinsteinDivision of Rheumatology, NYU Grossman School of Medicine, New York, NY.
Susan R S GottesmanDepartment of Cell Biology, NYU Grossman School of Medicine, New York, NY.
Cynthia LoomisDepartment of Pathology, NYU Grossman School of Medicine, New York, NY.
Zakia AzadDivision of Rheumatology, NYU Grossman School of Medicine, New York, NY.
Andy LeeDivision of Rheumatology, NYU Grossman School of Medicine, New York, NY.
Joshua PrasadDivision of Rheumatology, NYU Grossman School of Medicine, New York, NY.
Betsy BarnesInstitute for Molecular Medicine, Feinstein Institutes, New York, NY.
Mingyang YiDivision of Rheumatology, NYU Grossman School of Medicine, New York, NY.
Nimat UllahDivision of Rheumatology, NYU Grossman School of Medicine, New York, NY.
Nicolas GischDivision of Bioanalytical Chemistry, Research Center Borstel, Germany.
Kelly RugglesDivision of Precision Medicine, NYU Grossman School of Medicine, New York, NY.
Bhama RamkhelawonDepartment of Cell Biology, NYU Grossman School of Medicine, New York, NY.
Gregg J SilvermanDivision of Rheumatology, NYU Grossman School of Medicine, New York, NY.

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Translational Center of Molecular Profiling in Preclinical and Established Lupus (COMPEL)P50AR070591 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUYON, JILL P · 2017 to 2021
$6.7M
Gut dysbiosis and tryptophan metabolism in lupusR01AI143313 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Laurence Morel, Gregg Joshua Silverman · 2019 to 2026
$3.3M
Translational Basic and Clinical Research Training in RheumatologyT32AR069515 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jill P Buyon, Jose U. Scher · 2017 to 2026
$2.9M
Thromboinflammatory pathways triggered by gut dysbiosis in patients with LupusR21AI180737 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SILVERMAN, GREGG JOSHUA · 2024 to 2025
$460k
NCI NIH HHS P30 CA016087NIAID NIH HHS R01 AI143313NIAID NIH HHS R21 AI180737NIAMS NIH HHS P50 AR070591NIAMS NIH HHS T32 AR069515
6 · The paper itself

Abstract

Imbalances in the gut microbiome have been linked to increased intestinal permeability and disease flares in systemic lupus erythematosus (SLE). Our study revealed that patients with flares of lupus nephritis (LN) and intestinal expansions of the anaerobic commensal,

Indexed as

Dysbiosislupus nephritismicrobiomeNETosisplatelet activationthromboinflammation

Identifiers

PMID40667355
PMCPMC12262727

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.