Evidence map›Paper›PMID 40667326›Full record

ArticlebioRxiv : the preprint server for biology2025

YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast.

Elizabeth Abraham, Thomas Roule, Aidan Douglas, Emily Megill, Olivia M Pericak, Jordan E Howe, Carmen Choya-Foces, Joanne F Garbincius, Henry M Cohen, Paula Roig-Flórez and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Elizabeth AbrahamDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Thomas RouleRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Aidan DouglasDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Emily MegillDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Olivia M PericakDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Jordan E HoweDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Carmen Choya-FocesDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Joanne F GarbinciusDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Henry M CohenDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Paula Roig-FlórezDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Mikel ZubillagaDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Mark D AndrakeMolecular Modeling Facility, Program in Cancer Signaling and Microenvironment, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
Seonhee KimDepartment of Neural Sciences, Center for Neural Development and Repair, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
John W ElrodDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Naiara AkizuRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Conchi EstarasDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Eric Andrew Ross · 1985 to 2026
$138.8M
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2M
Integrative Cardiovascular PathophysiologyT32HL091804 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2008 to 2024
$4.5M
The role of EZH1 in neuronal differentiation and neurological disordersR01NS119699 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Naiara Akizu · 2022 to 2026
$2.8M
The Role of Hippo-Yap1 Signaling in Germ-layer SpecificationR01HD106969 · NICHD · TEMPLE UNIV OF THE COMMONWEALTH · PI Concepcion Estaras · 2022 to 2026
$2.1M
Molecular Biology and Genetics: Signaling, Epigenetics and Genome MaintenanceT32GM142606 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI Xavier Grana, Kelly A Whelan · 2021 to 2026
$1.5M
Investigating the role of YAP1 in blood cell specificationF31HD113419 · NICHD · TEMPLE UNIV OF THE COMMONWEALTH · PI ABRAHAM, ELIZABETH · 2024 to 2025
$47k
NCI NIH HHS P30 CA006927NCI NIH HHS P30 CA030199NHLBI NIH HHS T32 HL091804NICHD NIH HHS F31 HD113419NICHD NIH HHS R01 HD106969NIGMS NIH HHS T32 GM142606NINDS NIH HHS R01 NS119699
6 · The paper itself

Abstract

YAP1 signaling is essential for development but its specific roles in early embryogenesis remain poorly understood. To shed light on this, we analyzed YAP1's role in regulating the pluripotency of the mammalian epiblast, using scRNAseq approaches. Conditional deletion of

Indexed as

2D-gastruloidsepiblastNodal signalingpluripotencyQSER1Wnt signalingYAP1

Identifiers

PMID40667326
PMCPMC12262321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.