Evidence map›Paper›PMID 40667316›Full record

ArticlebioRxiv : the preprint server for biology2025

Combining Machine Learning and Multiplexed,

Michael J Leone, Robert van de Weerd, Ashley R Brown, Myung-Chul Noh, BaDoi N Phan, Andrew Z Wang, Kelly A Corrigan, Deepika Yeramosu, Heather H Sestili, Cynthia M Arokiaraj and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Michael J LeoneComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.
Robert van de WeerdComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.ORCID 0000-0002-6944-5433
Ashley R BrownComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.
Myung-Chul NohDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
BaDoi N PhanComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.ORCID 0000-0001-6331-5980
Andrew Z WangComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.
Kelly A CorriganDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Deepika YeramosuComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.
Heather H SestiliComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.ORCID 0000-0002-3944-3429
Cynthia M ArokiarajDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID 0000-0003-3201-9868
Bettega C LopesDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Vijay Kiran CherupallyComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.
Daryl FieldsDepartment of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Sudhagar BabuDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Chaitanya SrinivasanComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.
Riya PodderComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.
Lahari GadeyComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.ORCID 0000-0003-0914-2104
Daniel HeadrickDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Ziheng ChenComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.ORCID 0000-0001-5709-8529
Michael E FranusichComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.
Richard DumDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
David A LewisDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Hansruedi MathysDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
William R StaufferDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID 0000-0003-1031-8824
Rebecca P SealDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Andreas R PfenningComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.ORCID 0000-0002-3447-9801

Funding

Cell type specific AAVs to study reward and cognitionUF1MH130881 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BYRNE, LEAH, PFENNING, ANDREAS ROBERT · 2022 to 2022
$6.9M
A Massive Library of AAVs to Target Transcriptionally-Defined Primate Cell TypesUH3MH120094 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STAUFFER, WILLIAM RICHARD · 2023 to 2024
$3.1M
Dorsal horn circuits for mechanical allodyniaR01NS107364 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEAL, REBECCA P · 2019 to 2022
$2.1M
Investigation of Mechanical Allodynia Circuitry by the Nature of the InjuryR01NS139529 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REBECCA P SEAL · 2025 to 2026
$1.2M
Cell-type specific molecular and functional analyses to target dorsal horn pain circuitry in mice and non-human primatesR56NS133364 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PFENNING, ANDREAS ROBERT, SEAL, REBECCA P · 2023 to 2023
$499k
Integrating primate-rodent cell types and epigenomics to identify conservation in substance addictionF30DA053020 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PHAN, BADOI NGUYEN · 2021 to 2024
$204k
Identifying and targeting neural subpopulations of the spinal cord that mediate chronic pain via cell-type-specific cis-regulatory elementsF31NS134318 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI LEONE, MICHAEL · 2024 to 2025
$75k
NIDA NIH HHS F30 DA053020NIMH NIH HHS UF1 MH130881NIMH NIH HHS UH3 MH120094NINDS NIH HHS F31 NS134318NINDS NIH HHS R01 NS107364NINDS NIH HHS R01 NS139529NINDS NIH HHS R56 NS133364
6 · The paper itself

Abstract

A promising strategy for the precise control of neural circuits is to use

Identifiers

PMID40667316
PMCPMC12262481

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.