Evidence map›Paper›PMID 40667297›Full record

ArticlebioRxiv : the preprint server for biology2025

APALORD: An R-based tool for differential alternative polyadenylation analysis of long-read RNA-seq data.

Zhiping Zhang, Heather Glatt-Deeley, Lehan Zou, Dongyuan Song, Pedro Miura

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhiping ZhangDepartment of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, USA.
Heather Glatt-DeeleyDepartment of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0001-9948-1868
Lehan ZouDepartment of Biostatistics, The Mailman School of Public Health, Columbia University, New York City, NY, USA.
Dongyuan SongDepartment of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, USA.
Pedro MiuraDepartment of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0002-8434-5027

Funding

Scope and mechanism of coordinated alternative splicing and alternative polyadenylationR35GM138319 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Pedro Miura · 2020 to 2026
$3.0M
NIGMS NIH HHS R35 GM138319
6 · The paper itself

Abstract

Alternative polyadenylation (APA) is a critical co/post-transcriptional process that enhances RNA isoform diversity, regulating mRNA stability, localization and translation in a spatiotemporal manner. Over the past decade, long-read (LR) RNA sequencing techniques have advanced rapidly, producing datasets that could offer insights into APA mechanisms. Here we introduce

Indexed as

Alternative polyadenylation (APA)differential APAlong-read (LR) RNA-seqpolyadenylation site (PAS)

Identifiers

PMID40667297
PMCPMC12262201

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.