ArticlebioRxiv : the preprint server for biology2025
Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosis.
Taylor S Adams, Jonas C Schupp, Agshin Balayev, Johad Khoury, Aurélien Justet, Fadi Nikola, Laurens J De Sadeleer, Juan Cala-Garcia, Marta Zapata-Ortega, Panayiotis V Benos and 10 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
20 authors.
Taylor S AdamsSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Jonas C SchuppSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7714-8076 Agshin BalayevSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Johad KhourySection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8048-1542 Aurélien JustetSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Fadi NikolaSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Laurens J De SadeleerLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Juan Cala-GarciaSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Marta Zapata-OrtegaLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0003-0379-358X John E McDonoughSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2497-0258 Farida AhangariSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4144-9395 Melanie KönigshoffDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jun DingDepartment of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-5183-6885 Xiting YanSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8688-9004 Bart M VanaudenaerdeLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0001-6435-6901 Wim A WuytsLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0001-9648-3497 Naftali KaminskiSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5917-4601 Funding
Genomic Analysis of Tissue and Cellular Heterogeneity in IPFR01HL127349 · NHLBI · YALE UNIVERSITY · PI BENOS, PANAGIOTIS V, KAMINSKI, NAFTALI · 2015 to 2025
$5.9MEpithelial Protective Effects of Thyroid Hormone Signaling in FibrosisR01HL141852 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$3.4MNormal Aging Lung Cell Atlas (NALCA)U01HL145567 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$2.8MNovel Biomarkers for Post-Liver Transplant NASH FibrosisR01DK130294 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ARTEEL, GAVIN E, BENOS, PANAGIOTIS V · 2022 to 2025
$2.8MInterpretable graphical models for large multi-modal COPD data (R01HL159805)R01HL159805 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENOS, PANAGIOTIS V, SPIRTES, PETER · 2021 to 2024
$2.0MGraph Learning of Cell-cell Communications in Spatial TranscriptomicsR01LM014087 · NLM · YALE UNIVERSITY · PI WANG, ZUOHENG, YAN, XITING · 2022 to 2025
$1.5MNHLBI NIH HHS R01 HL127349NHLBI NIH HHS R01 HL141852NHLBI NIH HHS R01 HL159805NHLBI NIH HHS U01 HL145567NIDDK NIH HHS R01 DK130294NLM NIH HHS R01 LM014087
6 · The paper itselfAbstract
Acute and repetitive lung epithelial injury can lead to irreversible and even progressive pulmonary fibrosis; Idiopathic pulmonary fibrosis (IPF) is a fatal disease and quintessential example of this phenomenon. The composition of epithelial cells in human pulmonary fibrosis - irrespective of disease etiology - is marked by the presence of Aberrant Basaloid cells: an abnormal cell phenotype with pro-fibrotic and senescent features, localized to the surface of fibrotic lesions. Despite their relevance to human pulmonary fibrosis, the exotic molecular profile of Aberrant Basaloid cells has obscured their etiology, preventing insights into how or why these cells emerge with fibrosis. Here we identify cellular intermediaries between Aberrant Basaloid and normal alveolar epithelial cells in human IPF tissue. We track the emergence of Aberrant Basaloid cells from alveolar epithelial cells
Identifiers
PMID40667263
PMCPMC12262340
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390