Evidence map›Paper›PMID 40667219›Full record

ArticlebioRxiv : the preprint server for biology2025

TFAP2A+ embryonic progenitor cells undergo fate diversification to give rise to human amnion, germline, and mesoderm.

Auriana Arabpour, Jonathan Adam DiRusso, Qiu Ya Wu, Mark Larsen, Young Sun Hwang, Elsie Jacobson, Thi Xuan Ai Pham, Nicole Agranonik, Megan Sparrow, Vernon Leander Monteiro and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Auriana ArabpourDept. of Molecular, Cell, and Developmental Biology, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Jonathan Adam DiRussoDept. of Molecular, Cell, and Developmental Biology, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Qiu Ya WuDept. of Molecular, Cell, and Developmental Biology, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Mark LarsenDept. of Molecular, Cell, and Developmental Biology, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Young Sun HwangDept. of Molecular, Cell, and Developmental Biology, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Elsie JacobsonDept. of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Thi Xuan Ai PhamDept. of Development and Regeneration, Leuven Stem Cell Institute, Leuven Institute for Single-Cell Omics (LISCO), KU Leuven- University of Leuven, Leuven, Belgium.
Nicole AgranonikDept. of Molecular, Cell, and Developmental Biology, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Megan SparrowDept. of Molecular, Cell, and Developmental Biology, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Vernon Leander MonteiroDept. of Molecular, Cell, and Developmental Biology, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Zenya Rebecca BianDept. of Molecular, Cell, and Developmental Biology, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Nicolas Pelaez-RestrepoHoward Hughes Medical Institute (HHMI), Hanna H. Gray Fellows Program, USA.
Antuca Callejas-MarinDept. of Biology and Bioengineering, California Institute of Technology (Caltech); 1200 E. California Blvd., MC 114-96 Pasadena, CA 91125, USA.
Vincent PasqueDept. of Development and Regeneration, Leuven Stem Cell Institute, Leuven Institute for Single-Cell Omics (LISCO), KU Leuven- University of Leuven, Leuven, Belgium.ORCID 0000-0002-5129-0146
Kathrin PlathDept. of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.ORCID 0000-0001-7796-3372
Amander T ClarkDept. of Molecular, Cell, and Developmental Biology, University of California Los Angeles (UCLA); Los Angeles, CA 90095, USA.

Funding

Differentiating embryonic stem cells into developing germ lineR01HD079546 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLARK, AMANDER · 2015 to 2024
$3.7M
NICHD NIH HHS R01 HD079546
6 · The paper itself

Abstract

Amnion, germline and mesoderm specification at the posterior end of the human embryo occur around the same time

Indexed as

amnionEMTepiblastgerm cellslineage specificationmesodermTFAP2A

Identifiers

PMID40667219
PMCPMC12262574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.