Evidence map›Paper›PMID 40667213›Full record

ArticlebioRxiv : the preprint server for biology2025

Structure-specific Mini-Prion Model for Alzheimer's Disease Tau Fibrils.

Vishnu Vijayan, Gregory E Merz, Karen Tsay, Andrew P Longhini, Samuel Lobo, Athena Quddus, Kristi Lynn S Nakagawa, Michael P Vigers, Arthur A Melo, Eric Tse and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vishnu VijayanDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, USA.ORCID 0000-0002-3808-3556
Gregory E MerzInstitute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA.
Karen TsayDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, USA.
Andrew P LonghiniNeuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA, USA.
Samuel LoboDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA, USA.
Athena QuddusInstitute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA.
Kristi Lynn S NakagawaDepartment of Biological Sciences, Northwestern University, Evanston, IL, USA.
Michael P VigersDepartment of Chemistry, Northwestern University, Evanston, IL, USA.
Arthur A MeloInstitute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA.
Eric TseInstitute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA.
Joan-Emma SheaDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, USA.
M Scott ShellDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA, USA.
Kenneth S KosikNeuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA, USA.
Daniel R SouthworthInstitute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA.
Songi HanDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, USA.ORCID 0000-0001-6489-6246

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Molecular Basis of the Tau Aggregation PathwayR01AG056058 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Songi Han, KENNETH Stephen KOSIK · 2017 to 2026
$6.4M
Water as essential building blocks to direct protein structure and functionR35GM136411 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Songi Han · 2020 to 2026
$2.4M
NCI NIH HHS P30 CA060553NIA NIH HHS R01 AG056058NIGMS NIH HHS R35 GM136411
6 · The paper itself

Abstract

A critical discovery of the past decade is that tau protein fibrils adopt disease-specific hallmark structures in each tauopathy. The faithful generation of synthetic fibrils adopting hallmark structures that can serve as targets for developing diagnostic and/or therapeutic strategies remains a grand challenge. We report on a rational design of synthetic fibrils built of a short peptide that adopts a critical structural motif in tauopathy fibrils found in Alzheimer's Disease (AD) and Chronic Traumatic Encephalopathy (CTE). They serve as minimal prions with exquisite seeding competency,

Identifiers

PMID40667213
PMCPMC12262644

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.