ArticlebioRxiv : the preprint server for biology2025
MRI-Based Structural Development of the Human Newborn Hypothalamus.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Preclinical evidence suggests that intrauterine exposures can impact hypothalamic structure at birth and future disease risk, yet early human data are limited. Methods: Hypothalamic volumes were measured from 699 T1-weighted MRI scans from 631 newborns (54% female; 27-45 weeks postmenstrual age/PMA) in the Developing Human Connectome Project. Linear mixed-effects models tested associations with prenatal exposures: gestational age (GA) at birth, PMA at scan, sex, maternal body mass index (BMI), and smoking. Findings were partially replicated in the Adolescent Brain and Child Development (ABCD) Study (release 5.1) data (16,934 observations from 11,207 participants). Results: Absolute hypothalamus volume increased with PMA (+5.5%/week, t=39.9, p<10 Conclusions: The findings suggest that the hypothalamus is a crucial and underexplored target of perinatal influences for understanding the origins of long-term health and disease.
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