Evidence map›Paper›PMID 40667174›Full record

ArticlebioRxiv : the preprint server for biology2025

Stimulation modulates cell assemblies linked with gene networks in the human temporal cortex

H Moore, M Dehnad, A Freelin, B Granger, S Subramanian, A Kulkarni, S Berto, B C Lega, G Konopka

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

H MooreDepartment of Neuroscience and Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
M DehnadDepartment of Neuroscience and Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
A FreelinDepartment of Neuroscience and Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
B GrangerDepartment of Neuroscience and Bioinformatics Core, Medical University of South Carolina, Charleston, SC, USA.
S SubramanianDepartment of Neuroscience and Bioinformatics Core, Medical University of South Carolina, Charleston, SC, USA.
A KulkarniDepartment of Neuroscience and Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
S BertoDepartment of Neuroscience and Bioinformatics Core, Medical University of South Carolina, Charleston, SC, USA.
B C LegaDepartment of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
G KonopkaDepartment of Neuroscience and Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-3363-7302

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI John J Lemasters · 2009 to 2026
$42.7M
The Role of Early Life Stress in Feeding BehaviorsP20GM148302 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jose H Ledo · 2023 to 2026
$11.5M
Deciphering the genomic mechanisms underlying the physiology of human brain stimulationRF1NS126143 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI KONOPKA, GENEVIEVE, LEGA, BRADLEY C · 2022 to 2024
$4.0M
Deciphering the genomic mechanisms underlying the physiology of human brain stimulationR01NS126143 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI Genevieve Konopka, Bradley C Lega · 2025 to 2026
$2.2M
The role of SMAD3 in gene networks underlying human brain activityF31NS132443 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI MOORE, HALEY D · 2024 to 2025
$80k
NCI NIH HHS P30 CA138313NIGMS NIH HHS P20 GM148302NINDS NIH HHS F31 NS132443NINDS NIH HHS R01 NS126143NINDS NIH HHS RF1 NS126143
6 · The paper itself

Abstract

Deep brain stimulation of the temporal cortex can enhance learning and memory in the face of cognitive impairment. Despite the potential of such therapies, the neural and genetic mechanisms underlying the effect of stimulation on human brain circuits are not understood. To explicate direct mechanisms of neural modulation elicited by brain stimulation, we developed an

Identifiers

PMID40667174
PMCPMC12262240

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.