Evidence map›Paper›PMID 40667173›Full record

ArticlebioRxiv : the preprint server for biology2025

Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity.

Marisol Mancilla Moreno, Pooja J Patel, Kree Goss, Subhaan M Mian, Sera Nakisli, Nikhil Inturi, Stephanie I Shiers, Peter Horton, Anna Cervantes, Geoffrey Funk and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marisol Mancilla MorenoCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0000-0002-6479-4407
Pooja J PatelCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.
Kree GossCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0009-0008-0085-9954
Subhaan M MianCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0009-0007-0107-5521
Sera NakisliCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0000-0001-9426-1700
Nikhil InturiCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0009-0007-8688-6103
Stephanie I ShiersCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0000-0002-9646-1850
Peter HortonSouthwest Transplant Alliance, Dallas, TX 75231.
Anna CervantesSouthwest Transplant Alliance, Dallas, TX 75231.ORCID 0000-0001-9295-6648
Geoffrey FunkSouthwest Transplant Alliance, Dallas, TX 75231.
Tariq KhanSouthwest Transplant Alliance, Dallas, TX 75231.
Erin VinesSouthwest Transplant Alliance, Dallas, TX 75231.
Rebecca M KleinDepartment of Neuroscience, Merck & Co., Inc., Rahway, NJ 07065 USA.
Darrell A HenzeDepartment of Neuroscience, Merck & Co., Inc., Rahway, NJ 07065 USA.ORCID 0000-0001-5168-8413
Diana Tavares-FerreiraCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0000-0003-0986-3630
Theodore J PriceCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0000-0002-6971-6221
Muhammad Saad YousufCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0000-0003-0829-8182

Funding

Mechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Diana Tavares Ferreira · 2022 to 2026
$13.6M
Targeting methylglyoxal-induced diabetic neuropathic pain through the integrated stress responseR01DK134893 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI MUNMUN CHATTOPADHYAY, Muhammad Saad Yousuf · 2023 to 2026
$3.1M
NIDDK NIH HHS R01 DK134893NINDS NIH HHS U19 NS130608
6 · The paper itself

Abstract

The paravertebral sympathetic chain ganglia (SCG) are autonomic ganglia critical for regulating the "fight-or-flight" response. Symptoms of sympathetic dysfunction are prevalent in diabetes, affecting up to 90% of patients. The molecular and cellular composition of the human SCG and its alteration in diabetes remains poorly defined. To address this gap, we performed spatial transcriptomic profiling of lumbar SCGs from diabetic and non-diabetic organ donors. We identified 3 three distinct neuronal populations, two noradrenergic (NA1 and NA2) and one cholinergic (CHO), based on tyrosine hydroxylase (

Indexed as

diabetesdorsal root gangliadrug developmentspatial RNA sequencingsympathetic chain ganglia

Identifiers

PMID40667173
PMCPMC12262271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.