Evidence map›Paper›PMID 40667117›Full record

ArticlebioRxiv : the preprint server for biology2025

CHD4 and NKX2.2 Cooperate to Regulate Beta Cell Function by Repressing Non-Beta Cell Gene Programs.

Dylan K Sarbaugh, Thais Gaia Oliveira, Michelle A Guney, Victoria M Hoelscher, McKenna R Casey, Christopher J Hill, Cole R Michel, Kristen L Wells, Richard K P Benninger, Lori Sussel

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Dylan K SarbaughBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-8955-7424
Thais Gaia OliveiraBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Michelle A GuneyBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Victoria M HoelscherBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
McKenna R CaseyBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Christopher J HillBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Cole R MichelSchool of Pharmacy, Mass Spectrometry Facility, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kristen L WellsBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Richard K P BenningerBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Lori SusselBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-4672-7304

Funding

University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
Regulation of Pancreatic Islet Cell FateR01DK082590 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2009 to 2026
$7.3M
Emergent Multi-Cellular Properties Regulating Pancreatic Islet FunctionR01DK106412 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Richard KP Benninger · 2015 to 2026
$4.0M
Predoctoral Training Program in Molecular and Cellular Biology (Supplement: Mentoring in the Research Environment)T32GM136444 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI MICHAEL A MCMURRAY, Rytis Prekeris · 2020 to 2026
$3.7M
Multicellular Interactions and Dynamics of Pancreatic Islet Function in DiabetesR01DK102950 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BENNINGER, RICHARD KP · 2015 to 2024
$3.5M
Developing ultrasound contrast agents and signal processing for structural and functional imaging in type 1 diabetesR01DK140904 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Richard KP Benninger, Mark Andrew Borden · 2024 to 2026
$1.9M
NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK082590NIDDK NIH HHS R01 DK102950NIDDK NIH HHS R01 DK106412NIDDK NIH HHS R01 DK140904NIGMS NIH HHS T32 GM136444
6 · The paper itself

Abstract

NKX2.2 is a transcription factor that regulates pancreatic islet beta (β) cell identity and function; however, cofactor proteins that modulate the functional activity of NKX2.2 in β cells are relatively unexplored. An unbiased proteomics screen identified chromodomain helicase DNA-binding protein 4 (CHD4) as an NKX2.2 interacting partner. CHD4 is a nucleosome remodeler that directs the appropriate differentiation, maturation and function of many cell types. To characterize the roles of CHD4 in β cells, we generated

Identifiers

PMID40667117
PMCPMC12262308

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.