Evidence map›Paper›PMID 40667107›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular and Functional Analysis of Calcium Binding by a Cancer-linked Calreticulin Mutant.

Ishmael Nii Ayibontey Tagoe, Amanpreet Kaur, Osbourne Quaye, Emmanuel Ayitey Tagoe, Nicole Koropatkin, Leslie S Satin, Malini Raghavan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ishmael Nii Ayibontey TagoeDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI.
Amanpreet KaurDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI.ORCID 0000-0001-6806-8448
Osbourne QuayeWest African Centre for Cell Biology of Infectious Pathogens, Departments of Biochemistry, Cell and Molecular Biology, University of Ghana.ORCID 0000-0002-0621-876X
Emmanuel Ayitey TagoeMedical Laboratory Sciences, University of Ghana.ORCID 0000-0001-7179-1872
Nicole KoropatkinDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI.ORCID 0000-0002-2459-3336
Leslie S SatinDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI.
Malini RaghavanDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI.ORCID 0000-0002-1345-9318

Funding

METABOLICALLY-COUPLED ION CHANNEL INTERACTIONS IN ISLETSR01DK046409 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SATIN, LESLIE S. · 1994 to 2023
$9.1M
Calreticulin-mediated protein folding in health and diseaseR01AI123957 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGHAVAN, MALINI · 2016 to 2025
$3.7M
NIAID NIH HHS R01 AI123957NIDDK NIH HHS R01 DK046409
6 · The paper itself

Abstract

Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone with low affinity calcium binding sites in its C-terminal domain. This region is altered by somatic mutations in the CRT gene (

Identifiers

PMID40667107
PMCPMC12262281

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.