Evidence map›Paper›PMID 40667087›Full record

ArticlebioRxiv : the preprint server for biology2025

Integrating Artificial Intelligence-Driven Digital Pathology and Genomics to Establish Patient-Derived Organoids as a Novel Alternative Model for Drug Response in Head and Neck Cancer.

Rose Doerfler, Jie Chen, Carl Kim, Joshua D Smith, Micah Harris, Krishna B Singh, Brian Isett, Rebekah E Dadey, Daniel D Brown, Adrian V Lee and 19 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Rose DoerflerHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Jie ChenHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Carl KimHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Joshua D SmithHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Micah HarrisHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Krishna B SinghHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Brian IsettHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Rebekah E DadeyHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Daniel D BrownInstitute for Precision Medicine, UPMC, Pittsburgh, PA, USA.
Adrian V LeeInstitute for Precision Medicine, UPMC, Pittsburgh, PA, USA.ORCID 0000-0001-9917-514X
Xuefeng WangBiostatistics and Bioinformatics Program and Immuno-Oncology Program, Moffitt Cancer Center, Tampa, FL.ORCID 0000-0001-5775-408X
Matthew E SpectorHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Seungwon KimHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Shaum SridharanHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Kevin ContreraHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Katelyn SmithHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Carly ReederHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Maureen LyonsHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Jianhua LuoDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Silvia LiuOrgan Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Dan P ZandbergHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Heath D SkinnerHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Ioannis K ZervantonakisHillman Cancer Center, UPMC, Pittsburgh, PA, USA.ORCID 0000-0003-2386-9553
Lazar VujanovićHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Robert L FerrisHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Raja R SeethalaHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
José P ZevallosHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Jason J LukeHillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Riyue BaoHillman Cancer Center, UPMC, Pittsburgh, PA, USA.ORCID 0000-0002-6105-1704

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
WILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 2004 to 2026
$49.6M
Training in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2M
NCI ET-CTN with Phase i Emphasis at UPCIUM1CA186690 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD, Farshid Dayyani · 2014 to 2026
$9.1M
Immune Exclusion in Cancer ImmunotherapyR01DE031729 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Riyue Bao, Dan Paul Zandberg · 2022 to 2026
$3.0M
Postdoctoral Training in Head and Neck OncologyT32CA060397 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZEVALLOS, JOSE P. · 1994 to 2024
$2.7M
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA097190NCI NIH HHS T32 CA060397NCI NIH HHS T32 CA082084NCI NIH HHS UM1 CA186690NIDCR NIH HHS R01 DE031729NIH HHS S10 OD028483
6 · The paper itself

Abstract

Patient-derived organoids (PDOs) are emerging as advanced 3D

Indexed as

Artificial IntelligenceDigital pathologyDrug responseGenomicsHead and neck cancerHuman specimensNovel alternative modelOrganoids

Identifiers

PMID40667087
PMCPMC12262215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.