ArticlebioRxiv : the preprint server for biology2025
Image-Based Meta- and Mega-Analysis (IBMMA): A Unified Framework for Large-Scale, Multi-Site, Neuroimaging Data Analysis.
Abstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
99 authors.
Nick SteeleBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.ORCID 0009-0004-2308-163X
Rajendra A MoreyBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Ahmed HussainBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Courtney RussellBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Benjamin Suarez-JimenezDepartment of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.
Elena PozziCentre for Youth Mental Health, The University of Melbourne, Parkville, Australia.
Hadis JameeiCentre for Youth Mental Health, The University of Melbourne, Parkville, Australia.
Lianne SchmaalCentre for Youth Mental Health, The University of Melbourne, Parkville, Australia.
Ilya M VeerDepartment of Developmental Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Lea WallerCharité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.ORCID 0000-0003-4401-8950
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.ORCID 0000-0002-0046-4070
Lauren E SalminenImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Miranda OlffAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Jessie L FrijlingDe Viersprong mental health specialist in personality disorders, family and behavior, Amsterdam, The Netherlands.
Dick J VeltmanAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Saskia B J KochAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Laura NawijnAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Mirjam van ZuidenAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Li WangLaboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Ye ZhuLaboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Gen LiLaboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Dan J SteinSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Jonathan IpserSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Yuval NeriaDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Xi ZhuDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Orren RavidNew York State Psychiatric Institute, New York, NY, USA.
Sigal Zilcha-ManoUniversity of Haifa, Haifa, Israel.
Amit LazarovTel-Aviv University, Tel Aviv-Yafo, Israel.
Ashley A HugginsDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Kerry ResslerDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI, USA.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Sven C MuellerDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.ORCID 0000-0003-1661-3840
Anna R HudsonDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Judith K DanielsDepartment of Clinical Psychology, University of Groningen, Groningen, The Netherlands.
Anika SierkUniversity Medical Centre Charité, Berlin, Germany.
Antje MantheyUniversity Medical Centre Charité, Berlin, Germany.
Henrik WalterUniversity Medical Centre Charité, Berlin, Germany.
Nic J A van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-3235-1633
Steven J A van der WerffDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Robert R J M VermeirenDepartment of Child and Adolescent Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Christian SchmahlDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.
Julia I HerzogDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.
Ivan RektorCEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic.
Pavel ŘíhaFirst Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Milissa L KaufmanDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Lauren A M LeboisDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Justin T BakerDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Isabelle M RossoDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Elizabeth A OlsonDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Anthony KingDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Israel LiberzonDepartment of Psychiatry, Texas A&M University, Bryan, TX, USA.
Michael AngstadtDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Nicholas D DavenportMinneapolis VA Health Care System, Minneapolis, MN, USA.
Seth G DisnerMinneapolis VA Health Care System, Minneapolis, MN, USA.
Scott R SponheimMinneapolis VA Health Care System, Minneapolis, MN, USA.
Thomas StraubeInstitute of Medical Psychology and Systems Neuroscience, University of Mu nster, Mu nster, Germany.
David HofmannInstitute of Medical Psychology and Systems Neuroscience, University of Mu nster, Mu nster, Germany.
Guangming LuDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Rongfeng QiNanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Xin WangDepartment of Psychiatry, University of Toledo, Toledo, OH, USA.
Austin KunchDepartment of Psychiatry, University of Toledo, Toledo, OH, USA.
Hong XieDepartment of Psychiatry, University of Toledo, Toledo, OH, USA.
Yann QuidéSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Wissam El-HageUniversité de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, 37032, Tours, France.
Shmuel LissekDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Hannah BergDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Steven E BruceUniversity of Missouri-St. Louis, Department of Psychological Sciences, Center for Trauma Recovery, St. Louis, MO, USA.
Josh CislerDepartment of Psychiatry, University of Texas at Austin, Austin, TX, USA.
Marisa RossNorthwestern Neighborhood and Network Initiative, Northwestern University Institute for Policy Research, Evanston, IL, USA.
Ryan J HerringaSchool of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA.
Daniel W GrupeCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.
Jack B NitschkeDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Richard J DavidsonCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-8506-4964
Christine LarsonDepartment of Psychology, University of Wisconsin- Milwaukee, Milwaukee, WI, USA.
Terri A deRoon-CassiniDivision of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, WI, USA.
Carissa W TomasDepartment of Epidemiology, Institute of Health and Equity, Medical College of Wisconsin, WI, USA.
Jacklynn M FitzgeraldDepartment of Psychology, Marquette University, Milwaukee, WI, USA.
Jeremy ElmanDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.ORCID 0000-0002-5840-1769
Matthew PanizzonDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Carol E FranzDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Michael J LyonsDept. of Psychological & Brain Sciences, Boston University, Boston, MA, USA.
William S KremenDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Brandee FeolaDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, TN, USA.
Jennifer U BlackfordUniversity of Nebraska Medical Center, Munroe-Meyer Institute, Omaha, NE, USA.
Bunmi O OlatunjiDepartment of Psychology, Vanderbilt University, TN, USA.
Geoffrey MayCenter for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.
Steven M NelsonVeterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.
Evan M GordonDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Chadi G AbdallahDepartment of Psychiatry, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-5783-6181
Ruth LaniusDepartment of Neuroscience, Western University, London, ON, Canada.
Maria DensmoreDepartment of Psychiatry, Western University, London, ON, Canada.
Jean ThébergeDepartment of Psychiatry, Western University, London, ON, Canada.
Richard W J NeufeldDepartment of Psychiatry, Western University, London, ON, Canada.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.ORCID 0000-0002-4720-8867
Delin SunDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC, USA.ORCID 0000-0003-3283-423X
Funding
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0MAtlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8MWISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SVAREN, JOHN P · 1985 to 2015
$25.2MThe VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3MX LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI BRANN, ALFRED W · 1985 to 2007
$21.3MTR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MTRAINING PROGRAM IN EMOTION RESEARCHT32MH018931 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Richard J Davidson · 1989 to 2026
$11.6MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MNeural Substrates of Affective Style and Emotion RegulationR01MH043454 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J, SCHAEFER, STACEY M · 1989 to 2022
$9.6MGenetic and Trauma-Related Risk Factors for PTSDR01MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2005 to 2014
$8.5MTrauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4MEmory University BIRCWH ProgramK12HD085850 · NICHD · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, STERK, CLAIRE E · 2015 to 2023
$4.4MCSRD VA IK2 CX001680NCATS NIH HHS UL1 TR000454NCRR NIH HHS M01 RR000039NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG059874NIA NIH HHS R56 AG058854NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NICHD NIH HHS K12 HD085850NICHD NIH HHS P30 HD003352NICHD NIH HHS R01 HD071982NIMH NIH HHS K01 MH118428NIMH NIH HHS K01 MH118467NIMH NIH HHS R01 MH043454NIMH NIH HHS R01 MH071537NIMH NIH HHS R01 MH105355NIMH NIH HHS R01 MH106574NIMH NIH HHS R01 MH110483NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH113574NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH119227NIMH NIH HHS R01 MH120400NIMH NIH HHS R21 MH098198NIMH NIH HHS R21 MH098212NIMH NIH HHS R21 MH112956NIMH NIH HHS R56 MH071537NIMH NIH HHS T32 MH018931RRD VA I01 RX000622RRD VA IK1 RX002325RRD VA IK2 RX000709RRD VA IK2 RX002922
Abstract
The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited computational speed and inefficient memory allocation, and are restricted in the types of statistical designs they are able to model. We introduce Image-Based Meta- & Mega-Analysis (IBMMA), a novel software package implemented in R and Python that provides a unified framework for analyzing diverse neuroimaging features, efficiently handles large-scale datasets through parallel processing, offers flexible statistical modeling options, and properly manages missing voxel-data commonly encountered in multi-site studies. IBMMA produced stronger effect sizes and revealed findings in brain regions that traditional software overlooked due to missing voxel-data resulting in gaps in brain coverage. IBMMA has the potential to accelerate discoveries in neuroscience and enhance the clinical utility of neuroimaging findings.
Indexed as
Big DataMega-analysisMeta-analysisNeuroimagingPTSDResting-state fMRI
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.