Evidence map›Paper›PMID 40667070›Full record

ArticlebioRxiv : the preprint server for biology2025

Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study.

Xiao Shi, Michelle C Palumbo, Sheila Benware, Jack Wiedrick, Sheila Markwardt, Aaron Janowsky

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Xiao ShiResearch Service, Veterans Affairs Portland Health Care System, Portland OR 97239.ORCID 0000-0002-6944-9135
Michelle C PalumboDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland OR 97239 USA.
Sheila BenwareResearch Service, Veterans Affairs Portland Health Care System, Portland OR 97239.
Jack WiedrickBiostatistics & Design Program, OHSU-PSU School of Public Health, Oregon Health & Science University, Portland OR 97239 USA.
Sheila MarkwardtBiostatistics & Design Program, OHSU-PSU School of Public Health, Oregon Health & Science University, Portland OR 97239 USA.
Aaron JanowskyResearch Service, Veterans Affairs Portland Health Care System, Portland OR 97239.

Funding

Neuroscience of Aging, Neurodegeneration and Alzheimer’s DiseaseT32AG055378 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI JACOB RABER, HENRYK F URBANSKI · 2018 to 2026
$4.3M
BLRD VA IK6 BX005754NIA NIH HHS T32 AG055378
6 · The paper itself

Abstract

All cells secrete extracellular vesicles (EVs) containing nucleic acid cargo, including microRNAs (miRNAs), that regulate the function of receiving cells. G protein-coupled receptors (GPCRs) affect intracellular function via multiple signaling cascades. However, the mechanisms of GPCR intercellular signaling through EV miRNA activity are unknown. Human U2 osteosarcoma cells expressing native GPCRs were used to selectively stimulate distinct G protein signaling cascades (Gα

Indexed as

extracellular vesicleG protein-coupled receptormiRNAreceptor signalingU2OS

Identifiers

PMID40667070
PMCPMC12262688

What OpenQuestion holds

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LicenceCC0
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.