ArticlebioRxiv : the preprint server for biology2025
Exosomes are specialized vehicles to induce fibronectin assembly.
Bong Hwan Sung, Merlyn Emmanuel, Metti K Gari, Jorge F Guerrero, Maria Virumbrales-Muñoz, David Inman, Evan Krystofiak, Alan C Rapraeger, Suzanne M Ponik, Alissa M Weaver
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Bong Hwan SungDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine.
Merlyn EmmanuelDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine.
Metti K GariDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison School of Medicine and Public Health.
Jorge F GuerreroMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health.
Maria Virumbrales-MuñozDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison School of Medicine and Public Health.
David InmanDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison School of Medicine and Public Health.
Evan KrystofiakDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine.
Alan C RapraegerDepartment of Human Oncology, University of Wisconsin-Madison School of Medicine and Public Health.
Suzanne M PonikDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison School of Medicine and Public Health.ORCID 0000-0003-1367-4349 Alissa M WeaverDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine.ORCID 0000-0002-4096-8636 Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kevin L Schey · 1989 to 2026
$19.6MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MExosome secretion in breast cancer progressionR01CA206458 · NCI · VANDERBILT UNIVERSITY · PI PONIK, SUZANNE MARIE, WEAVER, ALISSA M · 2016 to 2025
$4.6MRegulation of extracellular vesicle biogenesis through cell adhesionR01CA249424 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PUA, HEATHER H, WEAVER, ALISSA M · 2020 to 2025
$2.6MExosomes in HNSCC ProgressionR01CA249684 · NCI · VANDERBILT UNIVERSITY · PI WEAVER, ALISSA M · 2021 to 2025
$2.0MExosome Secretion in Tumor AggressivenessR50CA283661 · NCI · VANDERBILT UNIVERSITY · PI Bong Hwan Sung · 2024 to 2026
$603kConventional 200 keV Transmission Electron MicroscopeS10OD034315 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEROME, WALTER G · 2023 to 2023
$597kNCI NIH HHS P30 CA068485NCI NIH HHS R01 CA206458NCI NIH HHS R01 CA249424NCI NIH HHS R01 CA249684NCI NIH HHS R50 CA283661NEI NIH HHS P30 EY008126NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIH HHS S10 OD034315
6 · The paper itselfAbstract
Fibronectin is a key stromal matrix molecule whose assembly into fibrils is thought to require cells. In contrast, we find that small exosome-type extracellular vesicles (EVs) are critical initiators of fibronectin assembly. Fibroblasts engineered to be deficient in exosome secretion showed greatly reduced assembly of fibronectin and other stromal matrix molecules in 2D, 3D, and
Identifiers
PMID40667058
PMCPMC12262568
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