Evidence map›Paper›PMID 40667056›Full record

ArticlebioRxiv : the preprint server for biology2025

Medial preoptic area FoxO1 controls metabolic adaptation in a sexually dimorphic manner.

Pei Luo, Xiaohua Yang, Qi Xu, Lau Lee How, Valeria C Torres Irizarry, Leslie Carrillo-Saenz, Marcos David Munoz, Wei Dong, Lucas Ibrahimi, Sarah Schaul and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Pei LuoDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Xiaohua YangDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Qi XuDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Lau Lee HowSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 639798, Singapore.
Valeria C Torres IrizarryDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Leslie Carrillo-SaenzDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Marcos David MunozDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Wei DongDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Lucas IbrahimiDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Sarah SchaulDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Nirali PatelDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Nimisha AntonyDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Devin DixitDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Maya KotaDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Christopher FreemanDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Elias L CruzThe Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois Chicago, Chicago, Illinois, 60612, USA.
Chunmei WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Graziano PinnaThe Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois Chicago, Chicago, Illinois, 60612, USA.
Yuwei JiangDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA.
Chong Wee LiewDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA.
Gang ShuGuangdong Laboratory of Lingnan Modern Agriculture and Guangdong Province Key Laboratory of Animal Nutritional Regulation, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, Guangdong, 510642, China.
Hui YeSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 639798, Singapore.
Yanlin HePennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, 70808, USA.
Terry UntermanDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Pingwen XuDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.ORCID 0000-0001-9363-4114

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Matthew J Brady · 2013 to 2026
$20.9M
The role of maternal obesity-driven inflammation and adverse pregnancy outcomes in a mouse model of preeclampsiaP20GM135002 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Timothy Allerton · 2020 to 2026
$18.4M
Alcohol Research Training in epigenetics and pathophysiology (ARTEP)T32AA026577 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SUBHASH C. PANDEY · 2019 to 2026
$2.7M
Regulation of beige adipocyte maintenance and its impact on metabolic outcomesR01DK132398 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Yuwei Jiang · 2022 to 2026
$2.6M
Testosterone and estrogen signaling pathways in the medial amygdala interact to control energy homeostasisR01DK123098 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI XU, PINGWEN · 2020 to 2024
$2.5M
GABA neurons in the ventromedial hypothalamus contribute to the counterregulatory responseR01DK129548 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Yanlin He · 2022 to 2026
$2.1M
EMC10, a novel obesity-regulated circulating factor, regulates energy and metabolic homeostasisR01DK109015 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIEW, CHONG WEE · 2016 to 2020
$1.8M
ESTROGEN-INDUCIBLE PNNS ENHANCE EXCITATORY SYNAPTIC STRENGTH ONTO GABA NEURONS IN THE MEPD TO PREVENT OBESITY AND METABOLIC DYSREGULATIONR01DK136627 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Chunmei Wang · 2023 to 2026
$1.8M
Short-Term Research Training Program in NIDDK Mission AreasT35DK131960 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Waddah A. Alrefai, JAMES P. LASH · 2022 to 2026
$400k
A novel brain-to-pancreatic islet neural circuit regulates glucose homeostasisR56DK133776 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI HE, YANLIN · 2023 to 2023
$213k
Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic AdaptationF31DK132918 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TORRES IRIZARRY, VALERIA CECILIA · 2023 to 2024
$97k
NIAAA NIH HHS T32 AA026577NIDDK NIH HHS F31 DK132918NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK109015NIDDK NIH HHS R01 DK123098NIDDK NIH HHS R01 DK129548NIDDK NIH HHS R01 DK132398NIDDK NIH HHS R01 DK136627NIDDK NIH HHS R56 DK133776NIDDK NIH HHS T35 DK131960NIGMS NIH HHS P20 GM135002
6 · The paper itself

Abstract

The medial preoptic area (MPOA) of the hypothalamus is essential for metabolic adaptation to environmental challenges, though the molecular mechanisms underlying this process remain poorly understood. Here, we investigate the role of Forkhead transcription factor O1 (FoxO1), a key mediator of stress adaptation, in MPOA-dependent metabolic responses to temperature and nutritional changes. Our findings reveal sex-specific responses to both nutritional and temperature challenges. In female mice, but not males, a high-fat diet (HFD) challenge decreased FoxO1 expression in the MPOA. Specific deletion of FoxO1 in MPOA neurons (FoxO1-KO

Indexed as

FoxO1MPOAsex difference

Identifiers

PMID40667056
PMCPMC12262617

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.