Evidence map›Paper›PMID 40667053›Full record

ArticlebioRxiv : the preprint server for biology2025

TDP-43 pathology induces CD8

Shahab Chizari, Matteo Zanovello, Steven Kong, Vidur Saigal, Anna-Leigh Brown, Valentina Turchetti, Luca Zampedri, Iwona Skorupinska, Giacomo Maria Minicuci, Francesca Paron and 20 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Shahab ChizariDepartment of Bioengineering, University of Pennsylvania, Philadelphia, USA.
Matteo ZanovelloDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.
Steven KongDepartment of Bioengineering, University of Pennsylvania, Philadelphia, USA.ORCID 0009-0004-1418-3001
Vidur SaigalDepartment of Bioengineering, University of Pennsylvania, Philadelphia, USA.
Anna-Leigh BrownDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.
Valentina TurchettiDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.
Luca ZampedriDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.
Iwona SkorupinskaDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.
Giacomo Maria MinicuciPadua Neuroscience Centre, University of Padua, Italy.
Francesca ParonInternational Centre for Genetic Engineering and Biotechnology.
Paola ToninDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.
Giulia MarchettoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.
Ziyi LiCenter for Alzheimer's and Related Dementias, NIH.
Jennifer M Colón-MercadoNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Dario DattiloDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.
Simone BarattucciDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.
Ariana GattDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.
Andy QiCenter for Alzheimer's and Related Dementias, NIH.
Michael HannaDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.
Michael WardCenter for Alzheimer's and Related Dementias, NIH.ORCID 0000-0002-5296-8051
Leonard PetrucelliMayo Clinic College of Medicine and Science, Mayo Clinic, USA.
Maurizio RomanoDepartment of Life Sciences, University of Trieste, Italy.ORCID 0000-0002-4820-2897
Gaetano VattemiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.
Emanuele BurattiInternational Centre for Genetic Engineering and Biotechnology.
Andrea MalapsinaDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.
Ashirwad MerveDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.
Pedro M MachadoDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.ORCID 0000-0002-8411-7972
Gianni SoraruPadua Neuroscience Centre, University of Padua, Italy.
Pietro FrattaDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.ORCID 0000-0002-7554-1632
Ning JiangDepartment of Bioengineering, University of Pennsylvania, Philadelphia, USA.

Funding

Human Biomarkers CoreU54NS123743 · NINDS · STANFORD UNIVERSITY · PI GITLER, AARON D. · 2021 to 2025
$8.2M
Immune System Development and RegulationT32AI055428 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M, OLIVER, PAULA MARIA · 2003 to 2025
$4.2M
Acquisition of a Cell Sorter for Systems Biology and Cellular EngineeringS10OD026986 · OD · UNIVERSITY OF PENNSYLVANIA · PI BUGAJ, LUKASZ · 2020 to 2020
$439k
NIAID NIH HHS T32 AI055428NIH HHS S10 OD026986NINDS NIH HHS U54 NS123743
6 · The paper itself

Abstract

Aggregation and nuclear depletion of the RNA binding protein TDP-43 are the crucial pathological features of amyotrophic lateral sclerosis (ALS) and inclusion body myositis (IBM), two degenerative diseases of the CNS and muscle. The loss of TDP-43 nuclear function results in the aberrant inclusion of cryptic exons in mRNA transcripts, leading to the expression of

Identifiers

PMID40667053
PMCPMC12262510

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.