Evidence map›Paper›PMID 40667047›Full record

ArticlebioRxiv : the preprint server for biology2025

Intra-Tumoral Treg Ablation Unleashes NK Cell-Mediated Control of CD8 T Cell-Resistant Tumors.

Chenyu Zhang, Charles Chien, Eglė Jurgaitytė, Koharu Sakiyama, Alissa Bockman, Yeara Jo, Seungwon Lee, Stephanie Silveria, Elizabeth Andrews, Abigail Mende and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Charles Chien
Eglė Jurgaitytė
Koharu Sakiyama
Alissa Bockman
Yeara Jo
Seungwon Lee
Stephanie Silveria
Elizabeth Andrews
Abigail Mende
Lily Zhang
K Christopher GarciaORCID 0000-0001-9273-0278
Michel DuPage

Funding

Mechanisms underlying combination therapy mobilizing NK cellsR01CA270790 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAVID H RAULET · 2022 to 2026
$2.3M
Immunosuppressive mechanisms of intratumoral regulatory T cellsR01CA292818 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Michel DuPage · 2025 to 2026
$1.2M
NCI NIH HHS R01 CA270790NCI NIH HHS R01 CA292818
6 · The paper itself

Abstract

Cancer cells frequently lose MHC I to evade CD8 One Sentence Summary: IT Treg ablation drives NK cell tumor control via CD4

Identifiers

PMID40667047
PMCPMC12262373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.