ArticlebioRxiv : the preprint server for biology2025
Prime assembly with linear DNA donors enables large genomic insertions.
Bin Liu, Andrew Petti, Xuntao Zhou, Haoyang Cheng, Lin Zhou, Tingting Jiang, Erik J Sontheimer, Wen Xue
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Bin LiuRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-3168-8456 Andrew PettiRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Xuntao ZhouRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Haoyang ChengRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Lin ZhouDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Tingting JiangIcahn Genomics Institute, Department of Immunology and Immunotherapy, Department of Oncological Sciences, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Erik J SontheimerRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-0881-0310 Wen XueRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-9797-8042 Funding
Vector Immunology CoreP01HL158506 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Terence R. Flotte · 2021 to 2026
$19.5MDevelop combinatorial non-viral and viral CRISPR delivery for lung diseasesUH3HL147367 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ANDERSON, DANIEL G, GAO, GUANGPING · 2021 to 2022
$2.9MIn vivo prime editing for precision cancer mouse modelsR01CA275945 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Wen Xue · 2023 to 2026
$2.5MDevelopment of a versatile paired prime editing toolkit for CFTR gene correctionR01HL178943 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Tingting Jiang · 2025 to 2026
$1.5MUsing base editing to investigate CFTR polymorphisms in lung diseasesR00HL153940 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JIANG, TINGTING · 2023 to 2025
$747kNCI NIH HHS R01 CA275945NHLBI NIH HHS P01 HL158506NHLBI NIH HHS R00 HL153940NHLBI NIH HHS R01 HL178943NHLBI NIH HHS UH3 HL147367
6 · The paper itselfAbstract
Targeted insertion of large DNA fragments has promising applications for genome engineering and gene therapy
Identifiers
PMID40667017
PMCPMC12262537
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