Evidence map›Paper›PMID 40667014›Full record

ArticlebioRxiv : the preprint server for biology2025

SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain.

Huijie Huang, Christina Huan Shi, Wenqi Yang, Juan Piña-Crespo, Jay Bhatnagar, Julian Curatolo, Rabi Murad, Palak Shah, Alex Campos, Alexandra Houser and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Huijie HuangCenter for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Christina Huan ShiCenter for Data Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Wenqi YangCenter for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Juan Piña-CrespoCenter for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Jay BhatnagarCenter for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Julian CuratoloCenter for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Rabi MuradBioinformatics Shared Resource, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Palak ShahCenter for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Alex CamposProteomics Core Facility, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Alexandra HouserCenter for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Rebecca A PorrittNCI-designated Cancer Center; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Tongmei ZhangCenter for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Qiang XiaoDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
Shengjie FengCenter for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Kevin Y YipCenter for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Timothy Y HuangCenter for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2M
Novel roles for the Alzheimer's Disease (AD) risk gene, SORLA in neuroprotection in ADR01AG061875 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI HUANG, TIMOTHY YIKAI · 2018 to 2022
$3.4M
Elucidating a microgliaassociated role for SORLA in modulating AD pathogenesisRF1AG070391 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI HUANG, TIMOTHY YIKAI · 2022 to 2022
$2.8M
Novel Neuroprotective Roles for the Alzheimer's Disease Risk Gene SORLA in Tau Pathology and PathogenesisR01AG085498 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Timothy Yikai Huang · 2024 to 2026
$2.6M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Digital Spatial Profiler Analysis InstrumentS10OD030285 · OD · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ADAMS, PETER D. · 2021 to 2021
$302k
NCI NIH HHS P30 CA030199NIA NIH HHS R01 AG061875NIA NIH HHS R01 AG085498NIA NIH HHS RF1 AG070391NIH HHS S10 OD026929NIH HHS S10 OD030285
6 · The paper itself

Abstract

A role for the trafficking receptor SORLA in reducing Aβ levels has been well-established, however, relatively little is known with respect to whether and how SORLA can potentially affect tau pathology

Indexed as

Alzheimer’s diseasePlexinsemaphorinSORL1SORLAtautauopathytau pathology

Identifiers

PMID40667014
PMCPMC12262635

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.