Evidence map›Paper›PMID 40666995›Full record

ArticlebioRxiv : the preprint server for biology2025

Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition.

Xiangyu Ge, Jaffarguriqbal Singh, Wenxue Li, Cassandra S Markham, Christian Felipe Ruiz, Moitrayee Bhattacharyya, Yansheng Liu, Mandar Deepak Muzumdar

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Xiangyu Ge
Jaffarguriqbal Singh
Wenxue Li
Cassandra S Markham
Christian Felipe Ruiz
Moitrayee Bhattacharyya
Mandar Deepak Muzumdar

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI Zhe Chen · 1985 to 2026
$85.0M
Dietary fatty acids drive pancreatic cancer developmentR01CA276108 · NCI · YALE UNIVERSITY · PI Mandar Deepak Muzumdar · 2023 to 2026
$2.6M
Defining tumor cell and host adaptations in cancer progressionDP2CA248136 · NCI · YALE UNIVERSITY · PI MUZUMDAR, MANDAR DEEPAK · 2019 to 2019
$2.5M
Molecular mechanism of regulation and activation of membrane proteins in native membrane milieuR35GM147095 · NIGMS · YALE UNIVERSITY · PI Moitrayee Bhattacharyya · 2022 to 2026
$2.0M
Elucidating KRAS-specific vulnerabilities in pancreatic cancerK08CA208016 · NCI · YALE UNIVERSITY · PI MUZUMDAR, MANDAR DEEPAK · 2016 to 2020
$880k
NCI NIH HHS DP2 CA248136NCI NIH HHS K08 CA208016NCI NIH HHS P30 CA016359NCI NIH HHS R01 CA276108NIGMS NIH HHS R35 GM147095
6 · The paper itself

Abstract

Despite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic

Identifiers

PMID40666995
PMCPMC12262375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.