Evidence map›Paper›PMID 40666966›Full record

ArticlebioRxiv : the preprint server for biology2025

Thymic DC2 are heterogenous and include a novel population of transitional dendritic cells.

Matouš Vobořil, Fernando Bandeira Sulczewski, Ryan J Martinez, K Maude Ashby, Michael Manoharan Valerio, Juliana Idoyaga, Kristin A Hogquist

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Matouš VobořilCenter for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Fernando Bandeira SulczewskiDepartment of Pharmacology, University of San Diego School of Medicine, San Diego, CA 92093, USA.
Ryan J MartinezCenter for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
K Maude AshbyCenter for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Michael Manoharan ValerioCenter for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Juliana IdoyagaDepartment of Pharmacology, University of San Diego School of Medicine, San Diego, CA 92093, USA.
Kristin A HogquistCenter for Immunology, Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Funding

Type I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUELLER, DANIEL L · 1993 to 2023
$31.1M
TCR signaling in thymic selection: Role of innate immune activationR01AI179749 · NIAID · UNIVERSITY OF MINNESOTA · PI Kristin A. Hogquist · 2024 to 2026
$1.9M
NIAID NIH HHS P01 AI035296NIAID NIH HHS R01 AI179749
6 · The paper itself

Abstract

Myeloid cells, including dendritic cells (DCs) and macrophages, are essential for establishing central tolerance in the thymus by promoting T cell clonal deletion and regulatory T cell (Treg) generation. Previous studies suggest that the thymic DC pool consists of plasmacytoid DC (pDC), XCR1

Identifiers

PMID40666966
PMCPMC12262426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.