Evidence map›Paper›PMID 40666952›Full record

ArticlebioRxiv : the preprint server for biology2025

Phase separation of PGL-3 driven by structured domains that oligomerize and interact with terminal RGG motifs.

Rimpei Kuroiwa, Piyoosh Sharma, Andrea Putnam, Stephen D Fried, Geraldine Seydoux

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Rimpei KuroiwaDepartment of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University, School of Medicine, Baltimore, MD 21205.ORCID 0009-0004-2199-2907
Piyoosh SharmaDepartment of Chemistry, Johns Hopkins University, School of Medicine, Baltimore, MD 21218.ORCID 0000-0002-1102-8602
Andrea PutnamDepartment of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University, School of Medicine, Baltimore, MD 21205.ORCID 0000-0001-7985-142X
Stephen D FriedDepartment of Chemistry, Johns Hopkins University, School of Medicine, Baltimore, MD 21218.ORCID 0000-0003-2494-2193
Geraldine SeydouxDepartment of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University, School of Medicine, Baltimore, MD 21205.ORCID 0000-0001-8257-0493

Funding

Watching Proteins Fold (or Misfold) in vivo with Mass SpectrometryDP2GM140926 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FRIED, STEPHEN DAVID · 2020 to 2020
$2.3M
NIGMS NIH HHS DP2 GM140926
6 · The paper itself

Abstract

Phase separation of biomolecular condensates is often assumed to be driven by interactions involving nucleic acids and intrinsically disordered regions (IDRs) of proteins. PGL-3 is a component of P granules, biomolecular condensates in the

Identifiers

PMID40666952
PMCPMC12262225

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.