Evidence map›Paper›PMID 40666903›Full record

ArticlebioRxiv : the preprint server for biology2025

CMV-specific clonal expansion of Th1, GZMK

Titas Grabauskas, Luke Trinity, Chris P Verschoor, Djamel Nehar Belaid, Radu Marches, Giray Eryilmaz, Avinash S Mahajan, Sathya Baarathi, Asa Thibodeau, Emilie Picard and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Titas GrabauskasThe Jackson Laboratory for Genomic Medicine; Farmington, CT 06030, USA.ORCID 0000-0002-3512-9862
Luke TrinityThe Jackson Laboratory for Genomic Medicine; Farmington, CT 06030, USA.
Chris P VerschoorHealth Sciences North Research Institute; NOSM University; Sudbury, ON P3E 2H3, Canada.
Djamel Nehar BelaidThe Jackson Laboratory for Genomic Medicine; Farmington, CT 06030, USA.
Radu MarchesThe Jackson Laboratory for Genomic Medicine; Farmington, CT 06030, USA.
Giray EryilmazThe Jackson Laboratory for Genomic Medicine; Farmington, CT 06030, USA.
Avinash S MahajanThe Jackson Laboratory for Genomic Medicine; Farmington, CT 06030, USA.
Sathya BaarathiThe Jackson Laboratory for Genomic Medicine; Farmington, CT 06030, USA.
Asa ThibodeauThe Jackson Laboratory for Genomic Medicine; Farmington, CT 06030, USA.
Emilie PicardHealth Sciences North Research Institute; NOSM University; Sudbury, ON P3E 2H3, Canada.
Chia-Ling KuoUniversity of Connecticut School of Medicine; Farmington, CT 06030, USA.
Kenneth E SchmaderDepartment of Medicine and Duke Center for the Study of Aging and Human Development (Aging Center), and GRECC, Durham VA Health Care System; Durham, NC 27705, USA.
Cathleen Colon EmericDepartment of Medicine and Duke Center for the Study of Aging and Human Development (Aging Center), and GRECC, Durham VA Health Care System; Durham, NC 27705, USA.
Heather E WhitsonDepartment of Medicine and Duke Center for the Study of Aging and Human Development (Aging Center), and GRECC, Durham VA Health Care System; Durham, NC 27705, USA.
Silke PaustThe Jackson Laboratory for Genomic Medicine; Farmington, CT 06030, USA.
Adolfo García SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA.
Gur YaariDepartment of Pathology, Yale School of Medicine, New Haven, CT 06510-3222, USA.
Jacques BanchereauThe Jackson Laboratory for Genomic Medicine; Farmington, CT 06030, USA.
George A KuchelUniversity of Connecticut School of Medicine; Farmington, CT 06030, USA.
Duygu UcarThe Jackson Laboratory for Genomic Medicine; Farmington, CT 06030, USA.

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI CATHLEEN S COLON-EMERIC, Susan Nicole Hastings · 2006 to 2026
$24.6M
Viral Immunity and VAccination (VIVA) Human Immunology Project Consortium (HIPC)U19AI168631 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Florian Krammer · 2022 to 2026
$14.4M
Research Education ComponentP30AG067988 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Richard H Fortinsky, GEORGE A KUCHEL · 2021 to 2026
$9.5M
A deep longitudinal analysis of next generation influenza vaccines in older adultsU01AI165452 · NIAID · JACKSON LABORATORY · PI Adolfo Garcia-Sastre, GEORGE A KUCHEL · 2022 to 2026
$9.0M
Physical Resiliencies: Indicators and Mechanisms in the Elderly CollaborativeUH3AG056925 · NIA · DUKE UNIVERSITY · PI COLON-EMERIC, CATHLEEN S · 2019 to 2021
$4.6M
Physical Resiliencies: Indicators and Mechanisms in the Elderly CollaborativeUH2AG056925 · NIA · DUKE UNIVERSITY · PI COLON-EMERIC, CATHLEEN S, WHITSON, HEATHER E. · 2017 to 2018
$2.0M
Training Program in Precision Genetics of Aging, Alzheimer's Disease and Related DementiasT32AG062409 · NIA · JACKSON LABORATORY · PI Gareth R Howell, KRISTEN M O'CONNELL · 2020 to 2026
$1.5M
NCI NIH HHS P30 CA034196NIAID NIH HHS 75N93021C00014NIAID NIH HHS U01 AI165452NIAID NIH HHS U19 AI168631NIA NIH HHS P30 AG028716NIA NIH HHS P30 AG067988NIA NIH HHS T32 AG062409NIA NIH HHS UH2 AG056925NIA NIH HHS UH3 AG056925
6 · The paper itself

Abstract

Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. We systematically characterized CMV-associated immune remodeling by analyzing six human cohorts (two newly built) using single-cell RNA sequencing, T cell receptor (TCR) sequencing, and flow cytometry. Beyond the well-known expansion of CD4

Identifiers

PMID40666903
PMCPMC12262386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.