ArticlebioRxiv : the preprint server for biology2025
Immunization with VLP-based vaccines induces high IgG antibody titers in dermal interstitial fluid.
Alexandra Francian, Srinivasa R Gadam, Aidan Leyba, Robert M Taylor, Pavan Muttil, Justin T Baca, Bryce Chackerian
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Alexandra FrancianDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Srinivasa R GadamDepartment of Emergency Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Aidan LeybaDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, New Mexico, USA.
Robert M TaylorDepartment of Emergency Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Pavan MuttilDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, New Mexico, USA.
Justin T BacaDepartment of Emergency Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Bryce ChackerianDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.ORCID 0000-0002-5712-4739 Funding
UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9MUnfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Judy Lin Cannon · 2017 to 2026
$24.9MFAIR Data Competency and Machine Learning Readiness for Biomedical ScientistsK12GM088021 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI REBECCA S. HARTLEY, Diane Lidke · 2009 to 2026
$16.4M University of New Mexico Clinical and Translational Science CenterKL2TR001448 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CANNON, JUDY LIN · 2015 to 2024
$3.5MVirus-like Particle based malaria vaccines targeting vulnerable epitopes in the circumsporozoite proteinR01AI169739 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Bryce C Chackerian · 2023 to 2026
$2.5MNCATS NIH HHS KL2 TR001448NCATS NIH HHS UL1 TR001449NIAID NIH HHS R01 AI169739NIGMS NIH HHS K12 GM088021NIGMS NIH HHS P20 GM121176
6 · The paper itselfAbstract
Although antibodies often exert their effects within the interstitium, the distribution of antibodies within extravascular tissue compartments is not typically measured. Here, IgG titers in peripheral blood and dermal interstitial fluid (ISF) were compared after intramuscular and intradermal immunization with virus-like particle (VLP)-based vaccines. Antibody titers and durability in serum and ISF were similar, indicating that VLP-based vaccines can efficiently elicit strong antibody responses in the skin.
Identifiers
PMID40666899
PMCPMC12262193
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