Evidence map›Paper›PMID 40666888›Full record

ArticlebioRxiv : the preprint server for biology2025

Cerebral vascular tortuosity and aneurysm formation and rupture: a novel vessel tortuosity scale.

Maxon V Knott, Naser Hamad, Pedro B Rodrigues, Sai Sanikommu, Jennifer S Suon, Helena Hernandez-Cuervo, Jayro Toledo, Ahmed Abdelsalam, Tiffany A Eatz, Victor J Del Brutto and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Maxon V KnottDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.
Naser HamadDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.
Pedro B RodriguesDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.
Sai SanikommuDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.
Jennifer S SuonDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.
Helena Hernandez-CuervoDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.
Jayro ToledoDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.
Ahmed AbdelsalamDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.
Tiffany A EatzDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.
Victor J Del BruttoDepartment of Neurology.
Evan M LutherDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.
Sanjoy K BhattacharyaDepartment of Ophthalmology, Bascom Palmer Eye Institute.
Joshua M HareInterdisciplinary Stem Cell Institute.ORCID 0000-0002-7751-5032
Michal ToborekDepartment of Biochemistry and Molecular Biology.
Roberto I Vazquez-PadronDepartment of Surgery.
John W ThompsonDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.
Robert M StarkeDepartment of Neurological Surgery, Radiology and the University of Miami Cerebrovascular Initiative.

Funding

Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
Institutional Career Development CoreKL2TR002737 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA, SCOTT, GWENDOLYN BARBARA · 2018 to 2022
$3.6M
Endothelial cell dysfunction in cerebral aneurysm pathogenesisR01NS111119 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI STARKE, ROBERT MICHAEL · 2020 to 2024
$2.4M
NCATS NIH HHS KL2 TR002737NCATS NIH HHS UL1 TR002736NINDS NIH HHS R01 NS111119
6 · The paper itself

Abstract

Cerebral aneurysm (CA) rupture is the most common cause of nontraumatic subarachnoid hemorrhage. Recent data suggests that tortuosity is associated with aneurysm formation and rupture risk. We aimed to determine if tortuosity correlates with CA development and rupture in a mouse CA model and to develop a novel tortuosity scale to be used for

Identifiers

PMID40666888
PMCPMC12262821

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.