ArticlebioRxiv : the preprint server for biology2025
Epilogos: information-theoretic navigation of multi-tissue functional genomic annotations.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
Functional genomics data, such as chromatin state maps, provide critical insights into biological processes, but are hard to navigate and interpret. We present Epilogos to address this challenge by offering a simple information-theoretic framework for large-scale visualization, navigation and interpretation of functional genomics annotations, and apply it to over 2,000 genome-wide chromatin state maps in human and mouse. We construct intuitive visualizations of multi-tissue chromatin state maps, prioritize salient genomic regions, identify group-wise differential regions, and enable rapid similarity search given a region of interest. To facilitate usability, we provide a purpose-built web-based browser interface (http://epilogos.net) alongside open-source software for community access and adoption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.