Evidence map›Paper›PMID 40666863›Full record

ArticlebioRxiv : the preprint server for biology2025

Fluidic Programmable Gravi-maze Array for High Throughput Multiorgan Drug Testing.

Henry C Wong, Chris J Collins, Joshna A Jude Jose, Isha N Bhakta, Andrew J Collins, Gunjan Katara, Johar Kohana, Harpreet S Saluja, John Collins

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Henry C WongBiopico Systems Inc, 188 Technology Dr, Suite G, Irvine CA 92618.
Chris J CollinsBiopico Systems Inc, 188 Technology Dr, Suite G, Irvine CA 92618.
Joshna A Jude JoseBiopico Systems Inc, 188 Technology Dr, Suite G, Irvine CA 92618.
Isha N BhaktaBiopico Systems Inc, 188 Technology Dr, Suite G, Irvine CA 92618.
Andrew J CollinsBiopico Systems Inc, 188 Technology Dr, Suite G, Irvine CA 92618.
Gunjan KataraBiopico Systems Inc, 188 Technology Dr, Suite G, Irvine CA 92618.
Johar KohanaBiopico Systems Inc, 188 Technology Dr, Suite G, Irvine CA 92618.
Harpreet S SalujaBiopico Systems Inc, 188 Technology Dr, Suite G, Irvine CA 92618.
John CollinsBiopico Systems Inc, 188 Technology Dr, Suite G, Irvine CA 92618.

Funding

CGMP Compliant Closed Cell Culture System for Reproducible De-differentiation of human somatic cells into iPSCsR44GM139413 · NIGMS · BIOPICO · PI COLLINS, JOHN · 2020 to 2021
$1.2M
A Humanized Organ Plate Paradigm for High Throughput Alzheimer's disease TherapeuticsR43AG073040 · NIA · BIOPICO · PI COLLINS, JOHN · 2021 to 2022
$459k
Fluidic Programmable Gravi-maze Array (FPGA) for Multi-organs Drug TestingR43ES032357 · NIEHS · BIOPICO · PI COLLINS, JOHN · 2020 to 2020
$251k
NIA NIH HHS R43 AG073040NIEHS NIH HHS R43 ES032357NIGMS NIH HHS R44 GM139413
6 · The paper itself

Abstract

The high attrition rate of drug candidates in clinical trials underscores the urgent need for more predictive preclinical models that accurately replicate human physiology. Traditional two-dimensional (2D) cell cultures and animal models often fail to predict human responses due to their limited physiological relevance. This highlights the need for modeling and measurements of multiorgan interactions at higher throughput prompting the development of multiorgan-on-a-plate (MOAP) platforms. Here, we present OrganRX

Identifiers

PMID40666863
PMCPMC12262207

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.