Evidence map›Paper›PMID 40666861›Full record

ArticlebioRxiv : the preprint server for biology2025

Alcohol consumption drives sex- and region- specific disruption of somatostatin signaling in mice.

Dakota F Brockway, Keith R Griffith, Andrew J Kacala, Lauren Bellfy, Laurel R Seemiller, Matthew Ulrich, Joseph M Ricotta, Md Shakhawat Hossain, Janine L Kwapis, Patrick J Drew and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dakota F BrockwayNeuroscience Graduate Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA 16802.
Keith R GriffithDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Andrew J KacalaDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Lauren BellfyDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Laurel R SeemillerDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Matthew UlrichBiomarker Core Laboratory, College of Health and Human Development, The Pennsylvania State University, University Park, PA, USA 16802.
Joseph M RicottaPenn State Neuroscience Institute, The Huck Institutes of the Life Sciences, University Park, PA, USA, 16802.
Md Shakhawat HossainPenn State Neuroscience Institute, The Huck Institutes of the Life Sciences, University Park, PA, USA, 16802.
Janine L KwapisDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.
Patrick J DrewDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.ORCID 0000-0002-7483-7378
Nicole A CrowleyDepartment of Biology, The Pennsylvania State University, University Park, PA, USA 16802.ORCID 0000-0002-1142-7929

Funding

Psychosocial Determinants and Biological Pathway to Healthy Aging (Pathways)T32AG049676 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI LYNN M. MARTIRE · 2016 to 2026
$3.9M
Imaging neurovascular coupling and functional connectivity in the behaving mouseR01NS078168 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI DREW, PATRICK JAMES · 2013 to 2023
$3.3M
Prelimbic somatostatin peptide signaling in binge ethanol consumptionR01AA029403 · NIAAA · PENNSYLVANIA STATE UNIVERSITY, THE · PI Nicole Ashley Crowley · 2022 to 2026
$1.9M
Diurnal control of memory allocation by the circadian gene Per1R01AG074041 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI JANINE LYNN KWAPIS · 2022 to 2026
$1.5M
Cross-Disciplinary Neural Engineering (CDNE) Training ProgramT32NS115667 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI GLUCKMAN, BRUCE J · 2021 to 2025
$1.1M
Sex differences in somatostatin cell dynamics and exploratory behavior after adolescent binge drinking in miceF32AA031396 · NIAAA · PENNSYLVANIA STATE UNIVERSITY, THE · PI Laurel Seemiller · 2024 to 2026
$225k
NIAAA NIH HHS F32 AA031396NIAAA NIH HHS R01 AA029403NIA NIH HHS R01 AG074041NIA NIH HHS T32 AG049676NINDS NIH HHS R01 NS078168NINDS NIH HHS T32 NS115667
6 · The paper itself

Abstract

The prefrontal cortex (PFC), which is thought to be disrupted early in the cycle of substance use and addiction [1], is comprised of a complex microcircuit of long-range glutamatergic pyramidal neurons controlled by GABAergic-expressing local inhibitory neurons [2, 3]. Somatostatin (SST)-expressing neurons are a subpopulation of these local GABAergic inhibitory cells and provide both peptidergic and GABAergic control over these PFC circuits [3, 4], and are disturbed following alcohol consumption in humans [5] and in rodent models [6, 7]. However, little is known about how endogenous SST peptide signaling is affected by alcohol. Using

Identifiers

PMID40666861
PMCPMC12262583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.