Evidence map›Paper›PMID 40666856›Full record

ArticlebioRxiv : the preprint server for biology2025

Melanocortin-responsive Kiss1 neurons of the arcuate nucleus drive energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus.

Rajae Talbi, Todd L Stincic, Nicole Lynch, Encarnacion Torres, Kaitlin Ferrari, Choi Ji Hae, Elizabeth Medve, Karol Walec, Samuel T Zdon, Sidney A Pereira and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rajae TalbiHarvard Medical School, Boston, MA, USA.ORCID 0000-0001-7158-6246
Todd L StincicDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.
Nicole LynchHarvard Medical School, Boston, MA, USA.
Encarnacion TorresHarvard Medical School, Boston, MA, USA.
Kaitlin FerrariHarvard Medical School, Boston, MA, USA.
Choi Ji HaeHarvard Medical School, Boston, MA, USA.
Elizabeth MedveHarvard Medical School, Boston, MA, USA.
Karol WalecHarvard Medical School, Boston, MA, USA.
Samuel T ZdonHarvard Medical School, Boston, MA, USA.
Sidney A PereiraHarvard Medical School, Boston, MA, USA.
Carrie E MahoneyHarvard Medical School, Boston, MA, USA.
Martha A BoschDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.
Larry ZweifelDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.
Oline K RønnekleivDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.
Natalia L S MachadoHarvard Medical School, Boston, MA, USA.
Martin J KellyDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.
Víctor M NavarroHarvard Medical School, Boston, MA, USA.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI HU, FRANK B · 1992 to 2021
$25.0M
The roles of NK3RMnPO and KNDy neurons in vasomotor symptoms, sleep, and cognition in E2 depleted mice.U54AG062322 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Ursula B. Kaiser · 2020 to 2026
$13.7M
Testosterone-GnRH Frequency and the Evolution of PCOS in AdolescenceP50HD028934 · NICHD · UNIVERSITY OF VIRGINIA · PI MCCARTNEY, CHRISTOPHER ROLLAND · 2014 to 2018
$8.6M
Sex Differences in the Control of FeedingR01DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2005 to 2024
$7.1M
Phasic Dopamine and Symptom Domains of Mental IllnessR01MH104450 · NIMH · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2015 to 2026
$5.5M
Characterization of the role of the amygdala in reproductive functionR01HD099084 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NAVARRO, VICTOR MANUEL · 2020 to 2024
$2.3M
Characterization of Kiss1 neurons as mediators of the reproductive regulation of energy balanceR01DK133760 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI NAVARRO, VICTOR MANUEL · 2022 to 2025
$2.2M
Dissecting the Role of Tachykinins in the Generation of GnRH PulsesR01HD090151 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NAVARRO, VICTOR MANUEL · 2017 to 2021
$1.7M
Crosstalk between Estrogen and Metabolic Hormone Signaling in Kisspeptin NeuronsR56DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2020 to 2020
$262k
NIA NIH HHS U54 AG062322NICHD NIH HHS P50 HD028934NICHD NIH HHS R01 HD090151NICHD NIH HHS R01 HD099084NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK068098NIDDK NIH HHS R01 DK133760NIDDK NIH HHS R56 DK068098NIMH NIH HHS R01 MH104450
6 · The paper itself

Abstract

Energy expenditure (EE) is essential for metabolic homeostasis, yet its central regulation remains poorly understood. Here, we identify arcuate Kiss1 neurons as key regulators of EE in male mice. Ablation of these neurons induced obesity, while their chemogenetic activation increased brown adipose tissue (BAT) thermogenesis without affecting food intake. This action is mediated by glutamatergic projections from Kiss1

Indexed as

DMHenergy expenditureKiss1 neuronsMC4Rmelanocortin systemmetabolismPOMC neuronsVglut2

Identifiers

PMID40666856
PMCPMC12262500

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.