Evidence map›Paper›PMID 40666852›Full record

ArticlebioRxiv : the preprint server for biology2025

Growth Arrest of Thoracic Aortic Aneurysms in Aging Marfan Mice.

Dar Weiss, Colin Means, Gavin Mays, Nicola Yeung, Cristina Cavinato, Edward P Manning, TuKiet T Lam, Jay D Humphrey

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Dar WeissDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.ORCID 0000-0001-6097-6038
Colin MeansDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
Gavin MaysDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
Nicola YeungSchool of Biological Sciences, University of Cambridge, Cambridge, UK.
Cristina CavinatoLMGC, University of Montpellier, CNRS, Montpellier, France.
Edward P ManningPulmonary and Critical Care Medicine, Yale School of Medicine, New Haven, CT, USA.
TuKiet T LamDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Jay D HumphreyDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.

Funding

TGFb-Dependent Cell-Matrix Interactions in Thoracic AortopathyP01HL169168 · NHLBI · YALE UNIVERSITY · PI Jay D. Humphrey · 2025 to 2026
$7.4M
Neural Operator Learning to Predict Aneurysmal Growth and OutcomesR01HL168473 · NHLBI · YALE UNIVERSITY · PI Roland Assi, Chiara Bellini · 2023 to 2026
$2.7M
ELUCIDATING MECHANISMS OF THORACIC AORTOPATHY VIA COMPUTATIONAL MODELINGR01HL169147 · NHLBI · YALE UNIVERSITY · PI Jay D. Humphrey, George Tellides · 2024 to 2026
$2.0M
6500 QTrap Mass Spectrometer for Yale UniversityS10OD018034 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2014 to 2014
$514k
Age-related Changes in the Pulmonary ArteryR03AG074063 · NIA · YALE UNIVERSITY · PI MANNING, EDWARD P · 2022 to 2023
$335k
An Ultra-Performance Liquid Chromatography System to Support Metabolomics at Yale UniversityS10OD019967 · OD · YALE UNIVERSITY · PI LAM, TUKIET T · 2015 to 2015
$135k
NHLBI NIH HHS P01 HL169168NHLBI NIH HHS R01 HL168473NHLBI NIH HHS R01 HL169147NIA NIH HHS R03 AG074063NIH HHS S10 OD018034NIH HHS S10 OD019967
6 · The paper itself

Abstract

There is a pressing need to identify pathologic mechanisms that render a thoracic aortic aneurysm susceptible to continued enlargement, dissection, or rupture, but additional insight can be gleaned by understanding potential compensatory mechanisms that prevent disease progression and thereby stabilize a lesion. Our biomechanical data suggest that the ascending aorta within a common mouse model of Marfan syndrome,

Indexed as

fibrillin-1inflammationproteomestiffnesstranscriptome

Identifiers

PMID40666852
PMCPMC12262233

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.