Evidence map›Paper›PMID 40666843›Full record

ArticlebioRxiv : the preprint server for biology2025

Epigenetic Programming of Estrogen Receptor in Adipose Tissue by High Fat Diet Regulates Obesity-Induced Inflammation.

Rui Wu, Fenfen Li, Shirong Wang, Jia Jing, Xin Cui, Yifei Huang, Xucheng Zhang, Jose A Carrillo, Zufeng Ding, Jiuzhou Song and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Rui WuSchool of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, P. R. China.
Fenfen LiDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Shirong WangDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Jia JingDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Xin CuiDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Yifei HuangDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Xucheng ZhangDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Jose A CarrilloDepartment of Animal and Avian Sciences, University of Maryland at College Park, College Park, MD 20742, USA.
Zufeng DingDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Jiuzhou SongDepartment of Animal and Avian Sciences, University of Maryland at College Park, College Park, MD 20742, USA.
Liqing YuDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Huidong ShiGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912.
Bingzhong XueDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Hang ShiDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.

Funding

HDAC1 as a nutrient sensor in the development and progression of NAFLDR01DK130342 · NIDDK · GEORGIA STATE UNIVERSITY · PI Hang Shi, Liqing Yu · 2022 to 2026
$2.8M
Crosstalk between sensory ghrelin signaling and adipose tissue sympathetic outflow regulates metabolic homeostasisR01DK125081 · NIDDK · GEORGIA STATE UNIVERSITY · PI XUE, BINGZHONG · 2020 to 2023
$2.3M
The Role of Adipocyte Lipolysis in ThermoregulationR01DK116496 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI YU, LIQING · 2018 to 2022
$1.8M
Impact of hemodynamics on efferocytosis in endothelial cellsR01HL162958 · NHLBI · UNIV OF ARKANSAS FOR MED SCIS · PI Zufeng Ding · 2022 to 2026
$1.7M
Epigenetic regulation of brown fat thermogenesis by the histone demethylase KDM6AR01DK118106 · NIDDK · GEORGIA STATE UNIVERSITY · PI SHI, HANG, XUE, BINGZHONG · 2019 to 2022
$1.7M
HDAC1 regulates thermogenic program via H3K27 deacetylationR01DK115740 · NIDDK · GEORGIA STATE UNIVERSITY · PI SHI, HANG · 2018 to 2021
$1.5M
Cellular and Molecular Mechanisms of Fatty Liver DiseaseR01DK111052 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI YU, LIQING · 2016 to 2019
$1.4M
Epigenetic programming of beta-klotho in non-alcoholic fatty liver diseaseR01DK116806 · NIDDK · GEORGIA STATE UNIVERSITY · PI SHI, HANG · 2018 to 2021
$1.4M
NHLBI NIH HHS R01 HL162958NIDDK NIH HHS R01 DK111052NIDDK NIH HHS R01 DK115740NIDDK NIH HHS R01 DK116496NIDDK NIH HHS R01 DK116806NIDDK NIH HHS R01 DK118106NIDDK NIH HHS R01 DK125081NIDDK NIH HHS R01 DK130342
6 · The paper itself

Abstract

Adipose inflammation plays a key role in obesity-induced metabolic abnormalities. Epigenetic regulation, including DNA methylation, is a molecular link between environmental factors and complex diseases. Here we found that high fat diet (HFD) feeding induced a dynamic change of DNA methylome in mouse white adipose tissue (WAT) analyzed by reduced representative bisulfite sequencing. Interestingly, DNA methylation at the promoter of estrogen receptor α (

Indexed as

Adipose inflammationDNA methylationEstrogen receptor

Identifiers

PMID40666843
PMCPMC12262827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.