ArticleFood science & nutrition2025
Luteolin Protects Against Acrylamide-Induced Cellular Toxicity in Mouse Leydig Cells.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Luteolin Protects Against Acrylamide-Induced Cellular Toxicity in Mouse Leydig Cells.Food science & nutrition · 2025Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Luteolin (Lut), a natural flavonoid, possesses the ability to protect the organism from reactive oxygen species (ROS) by modulating intracellular and extracellular signals. This study was conducted to investigate whether Lut exhibits a protective effect against acrylamide (Acr)-induced reproductive toxicity and to reveal the mechanisms underlying Leydig cell damage, a model cell in the male reproductive system. TM3 mouse Leydig cells were treated with Acr (1 mM) and/or Lut (1 and 5 μM) for 24 h. To determine the potential protective effects of Lut against the toxicity caused by Acr on Leydig cells, cell viability, combination index, and lactate dehydrogenase activity were examined for cytotoxicity. The effect of Lut on oxidative stress parameters in Acr-induced cellular damage was revealed by evaluating lipid peroxidation, total ROS, glutathione, and antioxidant enzymes (SOD, CAT, and GPx). In addition, we evaluated the expression levels of genes related to apoptosis (
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