ArticleFrontiers in veterinary science2025
Plasma and complement proteins are essential for the antimicrobial activity of canine platelet lysate.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Platelet Lysate-Based Biomaterials for Regenerative Tissue Engineering: A Comprehensive Review.International journal of nanomedicine · 2026Review
- Evaluation of multiple freeze-thaw cycles on growth factor and cytokine stability in canine platelet lysate: PDGF, TGF-Frontiers in veterinary science · 2026Article
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Authors and funding
8 authors.
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Abstract
Introduction: Platelet derived products have gained increasing attention as promising alternative biologicals for the treatment of canine wounds. Specifically, platelets play a crucial role during the inflammatory phase of wound healing due to the release of chemokines, proteins, cytokines, and growth factors. Additionally, platelets possess antimicrobial properties, which can be influenced by their manufacturing process, platelet and leukocyte concentration, activation method, and the presence of plasma and complement. The objective of this study was to assess how various preparation methods of platelet products affect their antimicrobial effect against bacteria commonly isolated from wounds. Methods: In this study, blood was collected from eight purpose-bred dogs, and platelet-rich plasma was produced using two methods of centrifugation, one leukocyte-enriching and one leukocyte-reducing. Some samples were processed for plasma depletion and platelet lysate was subsequently generated through freeze-thaw cycles. Additionally, portions of platelet lysate samples underwent heat treatment for complement inactivation. All treatment groups were tested against four common bacteria found in canine skin wounds: Results: Platelet lysate significantly reduced the number of Discussion: Therefore, the presence of plasma and complement proteins in platelet lysate appear to play a critical role in inhibiting the growth of certain bacterial strains, whereas the leukocyte concentration does not have a significant effect. Further research is needed to identify the ideal formulation and dose of canine platelet lysate as an antimicrobial and wound healing treatment.
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