Evidence map›Paper›PMID 40666705›Full record

ArticleJournal of translational gastroenterology

Autonomic-cyclooxygenase-2 Mechanisms of Electroacupuncture on Thermal Injury-induced Gastric Dysmotility in Rats.

Haixia Li, Jieyun Yin, Zhaohui Zhang, Hanaa S Sallam, Jiande D Z Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haixia LiDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, TX, USA.
Jieyun YinDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, TX, USA.
Zhaohui ZhangDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, TX, USA.
Hanaa S SallamDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, TX, USA.
Jiande D Z ChenDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, TX, USA.ORCID 0000-0002-0191-5697

Funding

Home-based transcutaneous electrical acustimulation for abdominal painUH3NS115108 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, JIANDE · 2022 to 2024
$1.9M
EFFECTS AND MECHANISMS OF CHRONIC ELECTROACUPUNCTURE FOR EMESISR21CA149956 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHEN, JIANDE · 2010 to 2011
$361k
NCI NIH HHS R21 CA149956NINDS NIH HHS UH3 NS115108
6 · The paper itself

Abstract

Background and objectives: Gastrointestinal dysmotility commonly follows thermal injuries, such as burns. This study aimed to investigate the effects and mechanisms of electroacupuncture (EA) on burn-induced gastric dysmotility in rats. Methods: Sprague-Dawley rats were divided into sham and thermal injury groups subjected to a 60% scald burn. Antagonists, including β-blockade (propranolol), α-blockade (phentolamine), or a selective cyclooxygenase (COX)-2 inhibitor (nimsulide), were administered to verify the pathways involved. Six hours after the burn, the animals were evaluated for gastric emptying and heart rate variability. Blood and gastric tissues were collected for assays of cytokines, hormones, and COX-2 levels. EA was performed at bilateral ST36 (Zusanli) acupoints for 45 m. Results: Burn injury delayed gastric emptying by 61% ( Conclusions: These findings suggest that burn-induced gastric dysmotility is mediated via autonomic-COX-2 pathways. EA at acupoint ST36 improves burn-induced delays in gastric emptying by down-regulating COX-2 and pro-inflammatory cytokines through the autonomic nervous pathway.

Indexed as

BurnCyclooxygenase-2CytokinesElectroacupunctureGastric emptyingNeuromodulation

Identifiers

PMID40666705
PMCPMC12263120

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.