ArticleBrain communications2025
Hyperuricaemia is associated with smaller volumes in the caudate nucleus head and putamen.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hyperuricaemia is a risk factor for gout, kidney diseases, and cerebrovascular diseases. Uric acid (UA) is also known as an antioxidant and has been suggested to inhibit the progression of neurodegenerative diseases, such as Parkinson's disease. However, only a few studies have focused on the potential effects of UA on the basal ganglia. This study aimed to measure UA levels and basal ganglia volumes in community-dwelling adults and to evaluate the association thereof. Blood UA levels and brain MRI data were collected from individuals who underwent brain health checkups between January 2015 and March 2022 at Shimane Institute of Health Science. Participants were classified into three groups based on their UA levels: normal-low UA (< 5.0 mg/dL), normal-high UA (5.0-7.0 mg/dL), and hyperuricaemia (> 7.0 mg/dL). MRI was used to assess the presence of asymptomatic infarcts, microbleeds, and the severity of enlarged perivascular spaces in the basal ganglia. The volumes of the caudate nucleus, globus pallidus, putamen, substantia nigra, and subthalamic nucleus were calculated using voxel-based morphometry (VBM) as
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