ArticleInternational journal of women's health2025
Causal Relationship Between Sex Hormone Binding Globulin and Obstetrical Disorders: A Two-Sample Bidirectional Mendelian Randomization Study.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Polymorphic Variant Associated with Sex Hormone-Binding Globulin Level Is a Risk Factor for Preeclampsia.International journal of molecular sciences · 2026Article
- FGF21 and SHBG as Putative Hepatic Axes in Maternal Metabolic Adaptation: A Hypothetical Framework for Postpartum Insulin Sensitivity Restoration.Biomolecules · 2026Review
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Authors and funding
5 authors.
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Abstract
Introduction: Obstetrical disorders critically impact maternal and fetal health. Sex hormone-binding globulin (SHBG) regulates pregnancy maintenance and maternal-infant outcomes through hormonal, metabolic, and inflammatory pathways, yet causal relationships with obstetrical disorders remain unclear. This Mendelian randomization (MR) study examined SHBG's causal effects on 12 obstetrical conditions. Methods: Using cis-protein quantitative trait loci (cis-pQTLs) of SHBG as instrumental variables, we conducted MR analyses in FinnGen and UK Biobank (UKBB), followed by meta-analyses. Inverse variance weighting (IVW) was primary method, with sensitivity analyses ensuring robustness. Results: IVW-MR demonstrated reduced risks with elevated SHBG: gestational diabetes (OR[95%]=0.835[0.785-0.889], Conclusion: SHBG causally lowers risks of gestational diabetes, hypertension, hyperemesis, miscarriage, and preterm delivery, highlighting its clinical relevance in obstetrical pathophysiology.
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