ArticleCureus2025
Metabolomic Analysis of Uremic Pruritus in Patients on Hemodialysis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Chronic Kidney Disease-Associated Pruritus in Hemodialysis: Unraveling Mechanisms and Emerging Therapeutic Targets-A Systematic Review.International journal of molecular sciences · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUremic pruritus (UP) is a prevalent and distressing complication among patients with end-stage renal disease (ESRD) receiving maintenance hemodialysis (HD). Despite its significant impact on quality of life and mortality, the underlying pathophysiology remains incompletely understood, with evidence implicating metabolic and inflammatory factors.
objectiveThis study aimed to determine the prevalence of UP and assess its association with selected metabolic and inflammatory biomarkers in patients undergoing maintenance HD.
methodsA cross-sectional observational study was conducted at the Dialysis Centre of Lahore General Hospital, a tertiary care hospital in Lahore, Pakistan. A total of 281 adult HD patients were enrolled. Pruritus was assessed using the 5-D Itch Scale, with a score ≥10 defining cases. Demographic and clinical data were recorded, and laboratory parameters including hemoglobin, calcium, phosphate, magnesium, intact parathyroid hormone (iPTH), uric acid, lipid profile, high-sensitivity C-reactive protein (hs-CRP), and white blood cell (WBC) count were analyzed. Associations were assessed using chi-square and independent samples t-tests. Multivariate logistic regression identified independent predictors of pruritus.
resultsThe prevalence of UP was 82 (29.2%). Significant differences were observed between pruritic and non-pruritic groups in age, dialysis duration, and several biochemical parameters. Independent predictors of pruritus included advancing age (OR = 1.148, p < 0.001), serum phosphate (OR = 2.069, p < 0.001), uric acid (OR = 1.680, p < 0.001), iPTH (OR = 1.007, p < 0.001), hs-CRP (OR = 1.596, p = 0.001), magnesium (OR = 9.687, p = 0.020), triglycerides (OR = 1.018, p = 0.025), and HCV infection (OR = 8.098, p = 0.001). No significant associations were found with gender, diabetes, dialysis frequency, or vascular access.
conclusionUP in HD patients is significantly associated with metabolic and inflammatory derangements rather than demographic or dialysis-related variables. These findings underscore the importance of targeted metabolic control and inflammation modulation in managing pruritus among dialysis populations.
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