Evidence map›Paper›PMID 40666568›Full record

ArticleCureus2025

A Rare Case of Polymicrobial Empyema Associated With COVID-19 Infection Complicated by a Bronchopleural Fistula.

Dhiraj R Regmi, Sandeep Kshetri, Laxman Wagle, Sabita Regmi

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dhiraj R RegmiInternal Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, NPL.
Sandeep KshetriInternal Medicine, MedStar Franklin Square Medical Center, Baltimore, USA.
Laxman WagleInternal Medicine, Ascension Saint Agnes Hospital, Baltimore, USA.
Sabita RegmiInternal Medicine, Tribhuvan University Institute of Medicine, Kathmandu, NPL.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Empyema is a rare but serious complication in patients with COVID-19, and its association with bronchopleural fistula (BPF) is even more uncommon. We present the case of a 40-year-old woman with a history of intravenous drug use who developed polymicrobial empyema in the setting of COVID-19, further complicated by BPF. She presented with hypoxic respiratory failure, leukocytosis, and lactic acidosis. Imaging revealed a large right-sided hydropneumothorax and bilateral lung opacities. Broad-spectrum antibiotics, antivirals, and corticosteroids were initiated, and 3 liters of purulent fluid were drained via chest tube, confirming empyema. Cultures identified multiple pathogens, including

Indexed as

antibioticsbacterial superinfectionbronchopleural fistulacovid-19covid pneumoniaempyemapleural fistulapolymicrobialthoracostomy

Identifiers

PMID40666568
PMCPMC12259386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.