Evidence map›Paper›PMID 40666518›Full record

ArticleFrontiers in immunology2025

Chronic ethanol administration exacerbates memory loss by altering N6-methyladenosine-mediated epigenetic signaling.

Yuanhang Liao, Fu Xu, Yuqing Yan, Sicheng Zhou, Na Liu, Baomin Dou, Nivetha Srinivasan, Weizheng Wang, Xiongwei Zhu, Jianghong Ye and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuanhang Liao *Department of Anesthesiology, Rutgers University, the State University of New Jersey, Newark, NJ, United States.
Fu Xu *Department of Anesthesiology, Rutgers University, the State University of New Jersey, Newark, NJ, United States.
Yuqing Yan *Department of Anesthesiology, Rutgers University, the State University of New Jersey, Newark, NJ, United States.
Sicheng ZhouDepartment of Anesthesiology, Rutgers University, the State University of New Jersey, Newark, NJ, United States.
Na LiuDepartment of Pharmaceutical Sciences, School of Pharmacy, SUNY at Buffalo, Buffalo, NY, United States.
Baomin DouDepartment of Anesthesiology, Rutgers University, the State University of New Jersey, Newark, NJ, United States.
Nivetha SrinivasanDepartment of Anesthesiology, Rutgers University, the State University of New Jersey, Newark, NJ, United States.
Weizheng WangDivision of Gastroenterology, Rutgers University, the State University of New Jersey, Newark, NJ, United States.
Xiongwei ZhuDepartment of Pathology, Case Western Reserve University, Cleveland, OH, United States.
Jianghong YeDepartment of Anesthesiology, Rutgers University, the State University of New Jersey, Newark, NJ, United States.
Ying XuDepartment of Anesthesiology, Rutgers University, the State University of New Jersey, Newark, NJ, United States.

Funding

Role of Mettl3-dependent RNA m6A dysregulation in Alzheimer's diseaseRF1AG083811 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI ZHU, XIONGWEI · 2023 to 2023
$2.2M
NIA NIH HHS RF1 AG083811
6 · The paper itself

Abstract

Background: Chronic alcohol use disorder (AUD) is recognized as one of the most critical risk factors for the progression of Alzheimer's disease (AD). Epigenetic and neuroimmune alterations are closely associated with the development of memory impairment related to AUD and AD. Methods: Adult APP/PS1 transgenic mice received intermittently intraperitoneal injections of ethanol (EtOH, 2.5 g/kg, i.p.) or vehicle with two "drug" treatment days, and one and two "drug-free" days every 7 days for 10 weeks. The novel object recognition (NOR) and Y-maze tests were performed to determine whether chronic ethanol treatment exacerbated memory impairment in these mice. The brain tissues were collected for pathological changes through MeRIP/RNA-sequence analyses and molecular biological assays. Results: The results suggested that chronic intermittent ethanol (CIE) treatment for 10 weeks exacerbated sporadic and spatial memory deficits in NOR and Y-maze tests in the APP/PS1 mice. The pathological assays revealed that CIE procedure increased Aβ plaque burden in the brain of the AD mice, which were consistent with memory behavioral deficits. The subsequent MeRIP/RNA sequence analyses showed that two genes, e.g. Rbm15b and Hnrnpa2b1, were related to N6-methyladenosine (m Conclusions: The conclusion is drawn that m

Indexed as

AdenosineEpigenesis, GeneticEthanolMemory DisordersAlzheimer DiseaseAnimalsDisease Models, AnimalMaleMiceMice, TransgenicSignal TransductionAdenosineEthanolN-methyladenosinechronic intermittent ethanolepigeneticsimmune cells infiltrationm 6 A modulationMeRIP/RNA sequence

Identifiers

PMID40666518
PMCPMC12259454

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.