Evidence map›Paper›PMID 40666509›Full record

ArticleFrontiers in immunology2025

Allergen-specific circulating CLA

Irene García-Jiménez, Lídia Sans-de San Nicolàs, Sandra Díez-Ribas, Laia Curto-Barredo, Marta Bertolín-Colilla, Ana Vivancos-Melenchón, Ignasi Figueras-Nart, Montserrat Bonfill-Ortí, Anna Ryzhkova, Marta Ferran and 3 more

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Irene García-JiménezImmunologia Translacional, Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc científic de Barcelona (PCB), Barcelona, Spain.
Lídia Sans-de San NicolàsImmunologia Translacional, Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc científic de Barcelona (PCB), Barcelona, Spain.
Sandra Díez-RibasImmunologia Translacional, Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc científic de Barcelona (PCB), Barcelona, Spain.
Laia Curto-BarredoDepartament de Dermatologia, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
Marta Bertolín-ColillaDepartament de Dermatologia, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
Ana Vivancos-MelenchónImmunologia Translacional, Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc científic de Barcelona (PCB), Barcelona, Spain.
Ignasi Figueras-NartDepartament de Dermatologia, Universitat de Barcelona (UB), L'Hospitalet de, Llobregat, Spain.
Montserrat Bonfill-OrtíDepartament de Dermatologia, Universitat de Barcelona (UB), L'Hospitalet de, Llobregat, Spain.
Anna RyzhkovaImmunologia Translacional, Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc científic de Barcelona (PCB), Barcelona, Spain.
Marta FerranDepartament de Dermatologia, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
Tali CzarnowickiDr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, United States.
Ramon M PujolDepartament de Dermatologia, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
Luis F Santamaria-BabíImmunologia Translacional, Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc científic de Barcelona (PCB), Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Current understanding of IL-22 in atopic dermatitis (AD) mostly relies on animal models, intracellular staining of polyclonally activated peripheral lymphocytes, and biological therapies. Methods: We evaluated the IL-22 response to house dust mite (HDM) extract in 58 patients with moderate-to-severe AD using a coculture system made of circulating memory cutaneous lymphocyte associated antigen (CLA) Results: HDM triggered heterogeneous IL-22 secretion in memory T cells, preferentially in the CLA Conclusions: This is the first report showing that allergen-specific CLA

Indexed as

AllergensAntigens, Differentiation, T-LymphocyteDermatitis, AtopicInterleukinsMemory T CellsSkinAdultAnimalsAntigens, DermatophagoidesFemaleHumansImmunoglobulin EImmunologic MemoryInterleukin-22MaleMembrane GlycoproteinsAllergensAntigens, DermatophagoidesAntigens, Differentiation, T-LymphocyteCTAGE1 protein, humanImmunoglobulin EInterleukin-22InterleukinsMembrane Glycoproteinsatopic dermatitisCLA+ memory T cellsepidermal thicknesshouse dust miteIgEIL-22moderate-to-severestratification

Identifiers

PMID40666509
PMCPMC12259416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.