Evidence map›Paper›PMID 40666486›Full record

ArticleACS medicinal chemistry letters2025

Design, Synthesis, and Biological Evaluation of Novel Hydroxyamidine Derivatives as Indoleamine 2,3-Dioxygenase 1 Inhibitors.

Xiaodan Qiu, Yitong Liu, Xia Zhou, Cong Zhao, Qingguo Meng, Wuli Zhao, Guangzhi Shan

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaodan QiuInstitute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, Tian Tan Xi Li No.1, Beijing 100050, PR China.
Yitong LiuInstitute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, Tian Tan Xi Li No.1, Beijing 100050, PR China.
Xia ZhouInstitute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, Tian Tan Xi Li No.1, Beijing 100050, PR China.
Cong ZhaoInstitute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, Tian Tan Xi Li No.1, Beijing 100050, PR China.
Qingguo MengSchool of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System & Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology & Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, PR China.
Wuli ZhaoInstitute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, Tian Tan Xi Li No.1, Beijing 100050, PR China.
Guangzhi ShanInstitute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, Tian Tan Xi Li No.1, Beijing 100050, PR China.ORCID https://orcid.org/0000-0003-0646-2874

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indoleamine 2,3-dioxygenase 1 (IDO1) is a rate-limiting enzyme that catalyzes the conversion of tryptophan into kynurenine and represents a potential target for tumor immunotherapy. In this study, we designed and synthesized a series of

Indexed as

hydroxyamidine derivativesIDO1tumor immunotherapy

Identifiers

PMID40666486
PMCPMC12257376

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.