Evidence map›Paper›PMID 40666354›Full record

ArticlemedRxiv : the preprint server for health sciences2025

A genome-wide association study of hidradenitis suppurativa from the VA's Million Veteran Program.

Zachary Wendland, Craig C Teerlink, Kathryn M Pridgen, Sydney Lo, Christopher Sayed, K R Van Straalen, Catherine Tcheandjieu, Philip S Tsao, Kyong-Mi Chang, Yun Li and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Zachary WendlandDepartment of Dermatology, Minneapolis VA Medical Center, Minneapolis, MN, USA.
Craig C TeerlinkVA Informatics and Computing Infrastructure (VINCI), VA Salt Lake City Healthcare System, Salt Lake City, UT, USA.
Kathryn M PridgenVA Informatics and Computing Infrastructure (VINCI), VA Salt Lake City Healthcare System, Salt Lake City, UT, USA.
Sydney LoSchool of Medicine, University of Minnesota, Minneapolis, MN, USA.
Christopher SayedDepartment of Dermatology, University of North Carolina, Chapel Hill, NC.
K R Van StraalenErasmus University Medical Center Rotterdam, Department of Dermatology, The Netherlands.
Catherine TcheandjieuVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID 0000-0001-9559-4339
Philip S TsaoVA Palo Alto Health Care System, Palo Alto, CA, USA.
Kyong-Mi ChangDepartment of Medicine, Corporal Michael J. Crescenz VA Medical Center & University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.ORCID 0000-0001-6811-9364
Yun LiDepartments of Genetics, University of North Carolina, Chapel Hill, NC.
Karen L MohlkeDepartments of Genetics, University of North Carolina, Chapel Hill, NC.
Quan SunDepartments of Biostatistics, University of North Carolina, Chapel Hill, NC.ORCID 0000-0001-8324-2803
Julie A LynchVA Informatics and Computing Infrastructure (VINCI), VA Salt Lake City Healthcare System, Salt Lake City, UT, USA.ORCID 0000-0003-0108-2127
Noah GoldfarbDepartment of Dermatology, Minneapolis VA Medical Center, Minneapolis, MN, USA.

Funding

Evaluation of the Genetics of Hidradenitis SuppurativaR21AR075996 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN, MOHLKE, KAREN L. · 2020 to 2021
$306k
BLRD VA I01 BX003362NIAMS NIH HHS R21 AR075996
6 · The paper itself

Abstract

Background: Data from family and twin studies as well as prior genome-wide association meta-analyses suggest that hidradenitis suppurativa (HS) has a hereditary component. Objective: Identify genetic variants associated with HS. Methods: A case-control genome-wide association study (GWAS) was performed on participants with a diagnosis of HS defined as at least one instance of ICD9 705.83 or ICD10 L73.2 from participants in the VA's Million Veteran Program. Results: 4,959 participants with HS were identified among 597,819 MVP participants. The multi-population GWAS identified two significant loci associated with HS, including a novel HS-related variant on chromosome 6 near Conclusion: The analysis of the MVP resource for HS identified a novel signal on chromosome 6 near

Identifiers

PMID40666354
PMCPMC12262797

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.