Evidence map›Paper›PMID 40666165›Full record

ArticleERS monograph2025

Advances in gas-exchange physiology and pathophysiology.

Susan R Hopkins, G Kim Prisk, Peter D Wagner

Abstract read
In one paragraph

Article in ERS monograph, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Susan R HopkinsPulmonary Imaging Laboratory, UC San Diego Health Sciences, La Jolla, CA.
G Kim PriskPulmonary Imaging Laboratory, UC San Diego Health Sciences, La Jolla, CA.
Peter D WagnerDepartment of Medicine, University of California, San Diego, La Jolla, CA.

Funding

Imaging of pulmonary arterial hypertension with proton MRIR56HL159710 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2022 to 2022
$684k
NHLBI NIH HHS R56 HL159710
6 · The paper itself

Abstract

Although respiratory gas exchange is a mature field, recent research brings new insights and techniques for patient evaluation. While some gases suffer pulmonary diffusion limitation, others do not, explained by comparing their solubility in the alveolar wall to their solubility (dissociation curve slope) in blood. Well-established concepts of shunt and deadspace are revisited with new computerized analyses and measurement approaches showing that in COVID-19, abnormal gas exchange reflects not just shunts but also alveolar deadspace suggesting vascular obstruction (sometimes persisting for months). So-called "silent hypoxia" in COVID-19 likely reflects normal variation in hypoxic ventilatory responsiveness; in most patients, arterial PCO

Indexed as

Gas-exchangephysiology and pathophysiology

Identifiers

PMID40666165
PMCPMC12260787

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.