Evidence map›Paper›PMID 40666105›Full record

ReviewFrontiers in oncology2025

Recent technical advancements and clinical applications of MR-guided radiotherapy in lung cancer treatment.

Chi Ma, Xiao Wang, Ke Nie, Zhenyu Xiong, Keying Xu, Ning Yue, Yin Zhang

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chi MaDepartment of Radiation Oncology, Rutgers Cancer Institute, New Brunswick, NJ, United States.
Xiao WangDepartment of Radiation Oncology, Rutgers Cancer Institute, New Brunswick, NJ, United States.
Ke NieDepartment of Radiation Oncology, Rutgers Cancer Institute, New Brunswick, NJ, United States.
Zhenyu XiongDepartment of Radiation Oncology, Rutgers Cancer Institute, New Brunswick, NJ, United States.
Keying XuDepartment of Radiation Oncology, Rutgers Cancer Institute, New Brunswick, NJ, United States.
Ning YueDepartment of Radiation Oncology, Rutgers Cancer Institute, New Brunswick, NJ, United States.
Yin ZhangDepartment of Radiation Oncology, Rutgers Cancer Institute, New Brunswick, NJ, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic resonance-guided radiotherapy (MRgRT) represents a significant advancement in lung cancer treatment, integrating non-ionizing high-resolution magnetic resonance imaging (MRI) with linear accelerators to enable real-time tumor visualization and adaptive treatment planning. This review highlights recent advancements in MRgRT technology and explores its clinical applications, particularly in managing lung cancer patients. MRgRT has proven particularly advantageous in stereotactic body radiotherapy (SBRT) treatment for lung cancer, where motion management is critical due to respiratory-induced tumor motion. Real-time tumor monitoring and online adaptive plan modifications ensure target accuracy, reduce margins, and mitigate radiation-induced toxicity. Additionally, MRgRT could potentially allow multileaf collimator (MLC) tracking to further improve the treatment efficiency. Recent technological innovations, including AI-powered auto-contouring algorithms, deep-learning (DL) based prediction models, and adaptive treatment strategies, further optimize MRgRT by improving workflow efficiency and reducing treatment time. Despite these benefits, the widespread adoption of MRgRT is challenged by high infrastructure costs, prolonged treatment time, and the need for specialized expertise. Ongoing research is addressing these challenges through workflow optimization, remote treatment models, and AI-driven decision support systems. As MRgRT technology continues to evolve, its integration with functional imaging, radiomics, and adaptive protocols is expected to expand its applications beyond lung cancer treatment. MRgRT represents a paradigm shift in precision oncology, delivering personalized care. Future research and prospective clinical trials should be warranted to generate high-quality clinical evidence supporting MRgRT's clinical adoption for lung cancer patient management. As these advancements progress, MRgRT is poised to transform the future of lung cancer treatment.

Indexed as

adaptive therapyartificial intelligencelung cancerlung SBRTmagnetic resonance-guided radiotherapy (MRgRT)radiomics

Identifiers

PMID40666105
PMCPMC12259636

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.