ArticleFrontiers in oncology2025
Global research trends in tryptophan metabolism and cancer: a bibliometric and visualization analysis (2005-2024).
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Tryptophan metabolism in tumor microenvironment and therapeutic implications.Journal of advanced research · 2026Review
- Metabolic collusion driving immune evasion in cholangiocarcinoma: unmasking the dual control of the immuno-metabolic microenvironment.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In recent years, tryptophan metabolism has gained increasing attention for its pivotal role in shaping the tumor immune microenvironment and promoting cancer progression. As a result, it has become a central topic in cancer metabolism and tumor immunology. This study applies a comprehensive bibliometric approach to analyze global research trends in tryptophan metabolism within the context of cancer. By identifying emerging hotspots, leading contributors, and patterns of international collaboration, this work aims to provide meaningful insights to guide future therapeutic strategies targeting metabolic pathways in oncology. Methods: A systematic literature search was performed using the Web of Science Core Collection to retrieve publications related to tryptophan metabolism in cancer from 2005 to 2024. Bibliometric and visual analyses were conducted using CiteSpace, VOSviewer, and Python to examine publication trends, national and institutional contributions, author productivity, journal influence, co-citation networks, and keyword co-occurrence patterns. Results: A total of 1,927 publications were identified, authored by 11,134 researchers from 70 countries and published in 781 academic journals. The volume of publications showed a steady increase, peaking in 2021. The United States and China emerged as the dominant contributors, excelling in both research output and international collaboration. Dietmar Fuchs was identified as the most prolific author, with 61 publications. The Medical University of Innsbruck was the leading institution, with 144 publications. Conclusion: This study highlights the growing significance of tryptophan metabolism research in cancer, underlining the complex interactions between metabolic pathways and immune responses. Further investigations are needed to explore the therapeutic potential of these metabolic pathways, which could lead to novel cancer treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.