ArticleOxford medical case reports2025
A case of classic epidermodysplasia verruciformis associated with elephantiasis: an atypical presentation.
Article in Oxford medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Epidermodysplasia verruciformis (EV) is a rare genetic skin disorder characterized by increased susceptibility to human papillomavirus infections (HPV) and a high risk of cutaneous carcinomas. We report the case of a 30-year-old female patient presenting with diffuse verrucous lesions, predominantly affecting the extremities, associated with unilateral elephantiasis. The diagnosis was histologically confirmed, revealing vulgar warts consistent with EV. HIV serology was negative, and systemic retinoid therapy was initiated. EV is linked to mutations in the EVER1 and EVER2 genes, predisposing patients to chronic infections with specific HPV types. Close monitoring is crucial to prevent malignant transformation. This case highlights the diagnostic and therapeutic challenges of EV, emphasizing the importance of an appropriate management strategy to control lesions and prevent complications.
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